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Tbio
ADO
2-aminoethanethiol dioxygenase

Protein Summary
Description
Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine (Dominy et al., 2007 [PubMed 17581819]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373783
  • ENSP00000362888
  • ENSG00000181915

Symbol
  • C10orf22
  • C10orf22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor binding site profile
0.9
disease perturbation
0.87
microRNA
0.76
histone modification site profile
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.75   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.75   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
ZNF212
Tdark
Family:  TF
Novelty:  0.68902645
p_int:  0.999995381
p_ni:  0.000003124
p_wrong:  0.000001495
Score:  0.209
Data Source:  BioPlex,STRINGDB
FCRL4
Tbio
Novelty:  0.03750876
p_int:  0.999977026
p_ni:  0.000022967
p_wrong:  7e-9
Score:  0.416
Data Source:  BioPlex,STRINGDB
SPANXN4
Tdark
Novelty:  1.91062423
p_int:  0.999960255
p_ni:  0.000037662
p_wrong:  0.000002083
Data Source:  BioPlex
GRP
Tbio
Novelty:  0.00034247
p_int:  0.891545486
p_ni:  0.000665876
p_wrong:  0.107788638
Data Source:  BioPlex
ANKRD39
Tdark
Novelty:  8.68843298
p_int:  0.86101344
p_ni:  0.000316601
p_wrong:  0.138669959
Data Source:  BioPlex
KCNJ10
Tbio
Family:  IC
Novelty:  0.00273462
p_int:  0.835732889
p_ni:  0.000012167
p_wrong:  0.164254944
Score:  0.219
Data Source:  BioPlex,STRINGDB
FAM76B
Tdark
Novelty:  0.80316253
p_int:  0.790716885
p_ni:  0.000031082
p_wrong:  0.209252033
Score:  0.513
Data Source:  BioPlex,STRINGDB
C5orf24
Tdark
Novelty:  3.95177775
p_int:  0.780608788
p_ni:  0.00001183
p_wrong:  0.219379382
Score:  0.188
Data Source:  BioPlex,STRINGDB
CSAD
Tbio
Family:  Enzyme
Novelty:  0.01293688
Score:  0.951
Data Source:  STRINGDB
GADL1
Tbio
Family:  Enzyme
Novelty:  0.018813
Score:  0.939
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Degradation of cysteine and homocysteine (R-HSA-1614558)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of cysteine and homocysteine
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Sulfur amino acid metabolism
Name
Explore in Pharos
Explore in Source
Degradation of cysteine and homocysteine
Metabolism
Metabolism of amino acids and derivatives
Sulfur amino acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
0
1.5
88.8
eosinophil count
1
2
2
76.5
lymphocyte count
2
1
2
72.3
1
1
0
1.7
68
platelet count
1
1
1
67.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
88.8
eosinophil count
2
76.5
lymphocyte count
2
72.3
0
1.7
68
platelet count
1
67.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
2-aminoethanethiol dioxygenase
VGNC:11624
748534
Macaque
2-aminoethanethiol dioxygenase
698259
Mouse
MGI:2685083
211488
Dog
2-aminoethanethiol dioxygenase
VGNC:37664
489003
Cow
2-aminoethanethiol dioxygenase
VGNC:25685
100297937
Species
Name
OMA
EggNOG
Inparanoid
Chimp
2-aminoethanethiol dioxygenase
Macaque
2-aminoethanethiol dioxygenase
Mouse
Dog
2-aminoethanethiol dioxygenase
Cow
2-aminoethanethiol dioxygenase
Publication Statistics
PubMed Score 19.75
PubMed score by year
PubTator Score 13.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title