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Tchem
ADK
Adenosine kinase

Protein Summary
Description
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286621
  • ENSP00000286621
  • ENSG00000156110
  • ENST00000372734
  • ENSP00000361819
  • ENST00000539909
  • ENSP00000443965
  • ENST00000541550
  • ENSP00000438321

Symbol
  • AK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.99
molecular function
0.96
transcription factor binding site profile
0.96
biological process
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 545.27   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 405   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 545.27   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 405   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 144
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (187)
FGB
Tbio
Novelty:  0.00437751
p_int:  0.999415969
p_ni:  0.0000038
p_wrong:  0.00058023
Score:  0.2
Data Source:  BioPlex,STRINGDB
ADA
Tclin
Family:  Enzyme
Novelty:  0.00072339
Score:  0.997
Data Source:  STRINGDB
APRT
Tchem
Family:  Enzyme
Novelty:  0.00483077
Score:  0.992
Data Source:  STRINGDB
ADSL
Tbio
Family:  Enzyme
Novelty:  0.0028496
Score:  0.989
Data Source:  STRINGDB
PNP
Tclin
Family:  Enzyme
Novelty:  0.0019084
Score:  0.989
Data Source:  STRINGDB
AMPD3
Tchem
Family:  Enzyme
Novelty:  0.01230806
Score:  0.98
Data Source:  STRINGDB
AK2
Tbio
Family:  Kinase
Novelty:  0.00581034
Score:  0.979
Data Source:  STRINGDB
AMPD2
Tchem
Family:  Enzyme
Novelty:  0.01510718
Score:  0.976
Data Source:  STRINGDB
ADA2
Tbio
Family:  Enzyme
Novelty:  0.01077582
Score:  0.97
Data Source:  STRINGDB
AMPD1
Tchem
Family:  Enzyme
Novelty:  0.00486439
Score:  0.97
Data Source:  STRINGDB
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
1 – 5 of 15
PDE8B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE1A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE4A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE4B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE3B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (581)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleotide salvage
Reactome
Purine salvage
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleotide salvage
Purine salvage
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tooth eruption
2
1
2
69.4
odontogenesis
1
1
1
65.4
body mass index
2
1
2
55.2
body height
1
1
1
48.5
platelet crit
1
1
1
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tooth eruption
2
69.4
odontogenesis
1
65.4
body mass index
2
55.2
body height
1
48.5
platelet crit
1
46.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenosine kinase
VGNC:3796
450902
Macaque
adenosine kinase
705246
Mouse
MGI:87930
11534
Rat
RGD:2046
25368
Dog
adenosine kinase
VGNC:37659
479253
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenosine kinase
Macaque
adenosine kinase
Mouse
Rat
Dog
adenosine kinase
Publication Statistics
PubMed Score 545.27
PubMed score by year
PubTator Score 248.18
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title