Tbio ADIPOQ Adiponectin

Protein Summary

Description

Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• Q15848
• Q58EX9

Gene Name

• ADIPOQ

Ensembl ID

• ENST00000320741
• ENSP00000320709
• ENSG00000181092
• ENST00000444204
• ENSP00000389814

Symbol

• ACDC
• ACRP30
• APM1
• GBP28
• ACDC
• ADPN
• APM1
• APM-1
• GBP28
• ACRP30
• ADIPQTL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
gene perturbation	1
chemical	0.99
PubMedID	0.81

Protein Classes

DTO Classes

Adiponectin Receptor Protein 1 / Adiponectin Receptor Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10069.85   (req: < 5)

Gene RIFs: 1963   (req: <= 3)

Antibodies: 1698   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10069.85   (req: >= 5)

Gene RIFs: 1963   (req: > 3)

Antibodies: 1698   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 81

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (367)

Explore Interacting Targets

1 – 10 of 367

• See Interactions on String-DB

C1QTNF4

Tbio

Novelty:  0.10701626

p_int:  0.999991484

p_wrong:  0.000008516

Data Source:  BioPlex

DNLZ

Tdark

Novelty:  0.10113346

p_int:  0.999950618

p_ni:  0.00004938

p_wrong:  2e-9

Data Source:  BioPlex

SHARPIN

Tbio

Novelty:  0.0197352

p_int:  0.99981851

p_ni:  0.000048553

p_wrong:  0.000132937

Data Source:  BioPlex

VHL

Tchem

Family:  Enzyme

Novelty:  0.00285782

p_int:  0.99906667

p_ni:  0.000933101

p_wrong:  2.29e-7

Data Source:  BioPlex

C1QL4

Tdark

Novelty:  0.37071722

p_int:  0.997084051

p_ni:  0.002824071

p_wrong:  0.000091878

Data Source:  BioPlex

PDP1

Tbio

Family:  Enzyme

Novelty:  0.00442352

p_int:  0.994541252

p_ni:  0.005458658

p_wrong:  9e-8

Data Source:  BioPlex

C1QL1

Tdark

Novelty:  0.11689088

p_int:  0.992985532

p_ni:  0.005846679

p_wrong:  0.001167789

Data Source:  BioPlex

COL14A1

Tbio

Novelty:  0.01760399

p_int:  0.991193932

p_ni:  0.008806066

p_wrong:  3e-9

Data Source:  BioPlex

HOMER1

Tbio

Novelty:  0.00264721

p_int:  0.954101443

p_ni:  0.045875017

p_wrong:  0.000023539

Data Source:  BioPlex

SEH1L

Tbio

Novelty:  0.03666501

p_int:  0.938956971

p_ni:  0.061043029

Data Source:  BioPlex

Nearest Tclin Targets (1)

Explore Nearest Tclin Targets

Downstream (1)

1 – 1 of 1

PPARA

Tclin

Family:  Nuclear Receptor

KEGG Distance:  1

Common Pathways:  3

1: Adipocytokine signaling pathway

2: Non-alcoholic fatty liver disease (NAFLD)

3: PPAR signaling pathway

Pathways (208)

Reactome (5)

KEGG (6)

WikiPathways (197)

AMPK inhibits chREBP transcriptional activation activity (R-HSA-163680)

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Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	AMPK inhibits chREBP transcriptional activation activity	8 targets	R-HSA-163680
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Integration of energy metabolism	111 targets	R-HSA-163685
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Transcriptional regulation of white adipocyte differentiation	84 targets	R-HSA-381340

Name	Explore in Pharos	Explore in Source
AMPK inhibits chREBP transcriptional activation activity	8 targets	R-HSA-163680
Developmental Biology	1055 targets	R-HSA-1266738
Integration of energy metabolism	111 targets	R-HSA-163685
Metabolism	2112 targets	R-HSA-1430728
Transcriptional regulation of white adipocyte differentiation	84 targets	R-HSA-381340

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (87)

Functions (7)

Components (6)

Processes (74)

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Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
hormone activity	Inferred from Direct Assay (IDA)	BHF-UCL
sialic acid binding	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Physical Interaction (IPI)	BHF-UCL
extracellular matrix structural constituent	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
signaling receptor binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
identical protein binding	Traceable Author Statement (TAS)	BHF-UCL
cytokine activity	Non-traceable Author Statement (NAS)	BHF-UCL

Disease Associations ()

No disease associations found

GWAS Traits (10)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 10

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
adiponectin measurement	EFO_0004502	6	5	6		98.6
BMI-adjusted adiponectin measurement	EFO_0007737	1	4	4		96.4
type II diabetes mellitus	EFO_0001360	6	4	3	1.1	92.4
reticulocyte measurement	EFO_0010700	2	1	2		79
eosinophil count	EFO_0004842	2	2	2		67.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
adiponectin measurement	EFO_0004502	6		98.6
BMI-adjusted adiponectin measurement	EFO_0007737	4		96.4
type II diabetes mellitus	EFO_0001360	3	1.1	92.4
reticulocyte measurement	EFO_0010700	2		79
eosinophil count	EFO_0004842	2		67.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Collagen
Complete proteome
Diabetes mellitus
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Hormone
Hydroxylation

GWAS Trait Find Similar Targets

No Header	No Header
adiponectin measurement
BMI-adjusted adiponectin measurement
drug-induced liver injury
eosinophil count
eosinophil percentage of leukocytes
HbA1c measurement
neuropathic pain
reticulocyte count
reticulocyte measurement
type II diabetes mellitus

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
liver/biliary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	adiponectin, C1Q and collagen domain containing	VGNC:11331	471032
Macaque	adiponectin, C1Q and collagen domain containing		574212
Mouse	adiponectin, C1Q and collagen domain containing	MGI:106675	11450
Rat	adiponectin, C1Q and collagen domain containing	RGD:628748	246253
Dog	adiponectin, C1Q and collagen domain containing	VGNC:37656	403625

Species	Name	OMA	EggNOG	Inparanoid
Chimp	adiponectin, C1Q and collagen domain containing
Macaque	adiponectin, C1Q and collagen domain containing
Mouse	adiponectin, C1Q and collagen domain containing
Rat	adiponectin, C1Q and collagen domain containing
Dog	adiponectin, C1Q and collagen domain containing

Publication Statistics

PubMed Score 10069.85

PubMed score by year

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PubTator Score 7090.35

PubTator score by year

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Related Publications

Text Mined References (2085)

GeneRif Annotations (1963)

Items per page:

10

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PMID	Year	Title