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Tbio
ADIPOQ
Adiponectin

Protein Summary
Description
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320741
  • ENSP00000320709
  • ENSG00000181092
  • ENST00000444204
  • ENSP00000389814

Symbol
  • ACDC
  • ACRP30
  • APM1
  • GBP28
  • ACDC
  • ADPN
  • APM1
  • APM-1
  • GBP28
  • ACRP30
  • ADIPQTL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
gene perturbation
1
chemical
0.99
PubMedID
0.81


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11132.37   (req: < 5)
Gene RIFs: 1963   (req: <= 3)
Antibodies: 1698   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11132.37   (req: >= 5)
Gene RIFs: 1963   (req: > 3)
Antibodies: 1698   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 81
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0