Tbio ADIPOQ Adiponectin

Protein Summary

Description

Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• Q15848
• Q58EX9

Gene Name

• ADIPOQ

Ensembl ID

• ENST00000320741
• ENSP00000320709
• ENSG00000181092
• ENST00000444204
• ENSP00000389814

Symbol

• ACDC
• ACRP30
• APM1
• GBP28
• ACDC
• ADPN
• APM1
• APM-1
• GBP28
• ACRP30
• ADIPQTL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
gene perturbation	1
chemical	0.99
PubMedID	0.81

Protein Classes

DTO Classes

Adiponectin Receptor Protein 1 / Adiponectin Receptor Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11132.37   (req: < 5)

Gene RIFs: 1963   (req: <= 3)

Antibodies: 1698   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11132.37   (req: >= 5)

Gene RIFs: 1963   (req: > 3)

Antibodies: 1698   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 81

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0