Protein Summary
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gen ...more
- ENST00000320741
- ENSP00000320709
- ENSG00000181092
- ENST00000444204
- ENSP00000389814
- ACDC
- ACRP30
- APM1
- GBP28
- ACDC
- ADPN
- APM1
- APM-1
- GBP28
- ACRP30
- ADIPQTL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
gene perturbation | 1 | ||
chemical | 0.99 | ||
PubMedID | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10069.85 (req: < 5)
Gene RIFs: 1963 (req: <= 3)
Antibodies: 1698 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10069.85 (req: >= 5)
Gene RIFs: 1963 (req: > 3)
Antibodies: 1698 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 81
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (367)
SHARPIN
Novelty: 0.0197352
p_int: 0.99981851
p_ni: 0.000048553
p_wrong: 0.000132937
Data Source: BioPlex
VHL
Family: Enzyme
Novelty: 0.00285782
p_int: 0.99906667
p_ni: 0.000933101
p_wrong: 2.29e-7
Data Source: BioPlex
C1QL4
Novelty: 0.37071722
p_int: 0.997084051
p_ni: 0.002824071
p_wrong: 0.000091878
Data Source: BioPlex
PDP1
Family: Enzyme
Novelty: 0.00442352
p_int: 0.994541252
p_ni: 0.005458658
p_wrong: 9e-8
Data Source: BioPlex
C1QL1
Novelty: 0.11689088
p_int: 0.992985532
p_ni: 0.005846679
p_wrong: 0.001167789
Data Source: BioPlex
COL14A1
Novelty: 0.01760399
p_int: 0.991193932
p_ni: 0.008806066
p_wrong: 3e-9
Data Source: BioPlex
HOMER1
Novelty: 0.00264721
p_int: 0.954101443
p_ni: 0.045875017
p_wrong: 0.000023539
Data Source: BioPlex
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (208)
Reactome (5)
KEGG (6)
WikiPathways (197)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | AMPK inhibits chREBP transcriptional activation activity | ||||
Reactome | Developmental Biology | ||||
Reactome | Integration of energy metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Transcriptional regulation of white adipocyte differentiation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
AMPK inhibits chREBP transcriptional activation activity | ||||
Developmental Biology | ||||
Integration of energy metabolism | ||||
Metabolism | ||||
Transcriptional regulation of white adipocyte differentiation | ||||
Viral Interactions (0)
Gene Ontology Terms (87)
Functions (7)
Components (6)
Processes (74)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
adiponectin measurement | 6 | 5 | 6 | 98.6 | |||||
BMI-adjusted adiponectin measurement | 1 | 4 | 4 | 96.4 | |||||
6 | 4 | 3 | 1.1 | 92.4 | |||||
reticulocyte measurement | 2 | 1 | 2 | 79 | |||||
eosinophil count | 2 | 2 | 2 | 67.4 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
adiponectin measurement | 6 | 98.6 | |||||
BMI-adjusted adiponectin measurement | 4 | 96.4 | |||||
3 | 1.1 | 92.4 | |||||
reticulocyte measurement | 2 | 79 | |||||
eosinophil count | 2 | 67.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | adiponectin, C1Q and collagen domain containing | VGNC:11331 | 471032 | |||||
Macaque | adiponectin, C1Q and collagen domain containing | 574212 | ||||||
Mouse | MGI:106675 | 11450 | ||||||
Rat | RGD:628748 | 246253 | ||||||
Dog | adiponectin, C1Q and collagen domain containing | VGNC:37656 | 403625 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | adiponectin, C1Q and collagen domain containing | |||||
Macaque | adiponectin, C1Q and collagen domain containing | |||||
Mouse | ||||||
Rat | ||||||
Dog | adiponectin, C1Q and collagen domain containing | |||||
Publication Statistics
PubMed Score 10069.85
PubMed score by year
PubTator Score 7090.35
PubTator score by year
Related Publications
Text Mined References (2085)
GeneRif Annotations (1963)
Items per page:
0 of 0
PMID | Year | Title |
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