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Tbio
ADH6
Alcohol dehydrogenase 6

Protein Summary
Description
This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237653
  • ENSP00000237653
  • ENSG00000172955
  • ENST00000394899
  • ENSP00000378359

Symbol
  • ADH-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
pathway
0.65
tissue sample
0.62
molecular function
0.6
cell line
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.13   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.13   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
ALDH3A2
Tbio
Family:  Enzyme
Novelty:  0.0059198
Score:  0.956
Data Source:  STRINGDB
CYP2E1
Tchem
Novelty:  0.00030504
Score:  0.936
Data Source:  STRINGDB
COMT
Tclin
Family:  Enzyme
Novelty:  0.00025107
Score:  0.93
Data Source:  STRINGDB
CYP26A1
Tchem
Family:  Enzyme
Novelty:  0.00281805
Score:  0.924
Data Source:  STRINGDB
AOX1
Tchem
Family:  Enzyme
Novelty:  0.0025823
Score:  0.915
Data Source:  STRINGDB
UGT2B10
Tbio
Family:  Enzyme
Novelty:  0.03135595
Score:  0.912
Data Source:  STRINGDB
LRAT
Tbio
Family:  Enzyme
Novelty:  0.00593203
Score:  0.906
Data Source:  STRINGDB
MAOA
Tclin
Family:  Enzyme
Novelty:  0.00031037
Score:  0.906
Data Source:  STRINGDB
SULT1A1
Tchem
Family:  Enzyme
Novelty:  0.00238409
Score:  0.902
Data Source:  STRINGDB
UGT2B11
Tbio
Family:  Enzyme
Novelty:  0.13396162
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets (8)
Explore Nearest Tclin Targets
Pathways (41)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Ethanol oxidation
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Ethanol oxidation
Metabolism
Phase I - Functionalization of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (57)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol use disorder measurement
6
6
3
6.2
99.6
alcohol dependence
4
6
0
1.8
99.6
alcohol consumption measurement
10
4
12
9.2
99.4
alcohol dependence measurement
2
6
7
99.2
3
1
1
1.9
94.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol use disorder measurement
3
6.2
99.6
alcohol dependence
0
1.8
99.6
alcohol consumption measurement
12
9.2
99.4
alcohol dependence measurement
7
99.2
1
1.9
94.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alcohol dehydrogenase 6 (class V)
461395
Macaque
alcohol dehydrogenase 6 (class V)
707585
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alcohol dehydrogenase 6 (class V)
Macaque
alcohol dehydrogenase 6 (class V)
Publication Statistics
PubMed Score 101.13
PubMed score by year
PubTator Score 17.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title