Protein Summary
The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
- ENST00000305046
- ENSP00000306606
- ENSG00000196616
- ENST00000394887
- ENSP00000378351
- ADH2
- ADH2
- HEL-S-117
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.89 | ||
PubMedID | 0.89 | ||
protein domain | 0.85 | ||
disease | 0.76 | ||
phenotype | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 539.83 (req: < 5)
Gene RIFs: 219 (req: <= 3)
Antibodies: 254 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 539.83 (req: >= 5)
Gene RIFs: 219 (req: > 3)
Antibodies: 254 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (2)
Protein-Protein Interactions (99)
ADH1C
Family: Enzyme
Novelty: 0.00507607
p_int: 1
Score: 0.973
Data Source: BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Pathways (28)
Reactome (4)
KEGG (8)
PathwayCommons (4)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Ethanol oxidation | ||||
Reactome | Metabolism | ||||
Reactome | Phase I - Functionalization of compounds | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Ethanol oxidation | ||||
Metabolism | ||||
Phase I - Functionalization of compounds | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (2)
Components (3)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (40)
Items per page:
1 – 5 of 40
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
alcohol consumption measurement | 14 | 17 | 32 | 9.2 | 99.9 | ||||
alcohol use disorder measurement | 6 | 6 | 4 | 7.2 | 99.4 | ||||
6 | 8 | 0 | 1.6 | 99 | |||||
alcohol dependence measurement | 2 | 8 | 9 | 97.7 | |||||
IGF-1 measurement | 1 | 3 | 3 | 91.6 | |||||
Items per page:
1 – 5 of 40
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
alcohol consumption measurement | 32 | 9.2 | 99.9 | ||||
alcohol use disorder measurement | 4 | 7.2 | 99.4 | ||||
0 | 1.6 | 99 | |||||
alcohol dependence measurement | 9 | 97.7 | |||||
IGF-1 measurement | 3 | 91.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (1)
1 – 1 of 1
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | alcohol dehydrogenase 1B (class I), beta polypeptide | 461396 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | alcohol dehydrogenase 1B (class I), beta polypeptide | |||||
Publication Statistics
PubMed Score 539.83
PubMed score by year
PubTator Score 356.05
PubTator score by year
Related Publications
Text Mined References (365)
GeneRif Annotations (219)
Items per page:
0 of 0
PMID | Year | Title |
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