Protein Summary
This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010]
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 482.79 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 241 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 482.79 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 241 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (5)
Protein-Protein Interactions (105)
Nearest Tclin Targets
Pathways (22)
Reactome (10)
KEGG (8)
PathwayCommons (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Abacavir metabolism | ||||
Reactome | Abacavir transport and metabolism | ||||
Reactome | Biological oxidations | ||||
Reactome | Ethanol oxidation | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Abacavir metabolism | ||||
Abacavir transport and metabolism | ||||
Biological oxidations | ||||
Ethanol oxidation | ||||
Metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (4)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (40)
Items per page:
1 – 5 of 40
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
alcohol consumption measurement | 14 | 18 | 33 | 9.2 | 99.9 | ||||
alcohol use disorder measurement | 6 | 7 | 4 | 8 | 99.5 | ||||
6 | 8 | 0 | 1.6 | 99 | |||||
alcohol dependence measurement | 2 | 9 | 10 | 97.8 | |||||
IGF-1 measurement | 1 | 3 | 3 | 91.6 | |||||
Items per page:
1 – 5 of 40
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
alcohol consumption measurement | 33 | 9.2 | 99.9 | ||||
alcohol use disorder measurement | 4 | 8 | 99.5 | ||||
0 | 1.6 | 99 | |||||
alcohol dependence measurement | 10 | 97.8 | |||||
IGF-1 measurement | 3 | 91.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (3)
1 – 3 of 3
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:87921 | 11522 | ||||||
Dog | alcohol dehydrogenase E chain | 100856533 | ||||||
Opossum | alcohol dehydrogenase S chain-like | 100015889 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Dog | alcohol dehydrogenase E chain | |||||
Opossum | alcohol dehydrogenase S chain-like | |||||
Publication Statistics
PubMed Score 482.79
PubMed score by year
PubTator Score 189.34
PubTator score by year
Related Publications
Text Mined References (47)
GeneRif Annotations (17)
Items per page:
0 of 0
PMID | Year | Title |
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