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Tclin
ADH1A
Alcohol dehydrogenase 1A

Protein Summary
Description
This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000209668
  • ENSP00000209668
  • ENSG00000187758

Symbol
  • ADH1
  • ADH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
pathway
0.75
PubMedID
0.65
disease
0.63
phenotype
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 482.79   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 482.79   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (105)
ADH1B
Tclin
Family:  Enzyme
Novelty:  0.00204308
Score:  0.982
Data Source:  Reactome,STRINGDB
CYP2E1
Tchem
Novelty:  0.00030504
Score:  0.962
Data Source:  STRINGDB
CYP26A1
Tchem
Family:  Enzyme
Novelty:  0.00281805
Score:  0.935
Data Source:  STRINGDB
LRAT
Tbio
Family:  Enzyme
Novelty:  0.00593203
Score:  0.935
Data Source:  STRINGDB
AOX1
Tchem
Family:  Enzyme
Novelty:  0.0025823
Score:  0.929
Data Source:  STRINGDB
RETSAT
Tdark
Family:  Enzyme
Novelty:  0.10624626
Score:  0.922
Data Source:  STRINGDB
ADH1C
Tclin
Family:  Enzyme
Novelty:  0.00507607
Score:  0.916
Data Source:  Reactome,STRINGDB
ALDH2
Tclin
Family:  Enzyme
Novelty:  0.00077122
Score:  0.909
Data Source:  STRINGDB
BCO1
Tbio
Family:  Enzyme
Novelty:  0.00784197
Score:  0.905
Data Source:  STRINGDB
PNPLA4
Tbio
Family:  Enzyme
Novelty:  0.07471752
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Abacavir metabolism (R-HSA-2161541)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abacavir metabolism
Reactome
Abacavir transport and metabolism
Reactome
Biological oxidations
Reactome
Ethanol oxidation
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Abacavir metabolism
Abacavir transport and metabolism
Biological oxidations
Ethanol oxidation
Metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
14
18
33
9.2
99.9
alcohol use disorder measurement
6
7
4
8
99.5
6
8
0
1.6
99
alcohol dependence measurement
2
9
10
97.8
IGF-1 measurement
1
3
3
91.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
33
9.2
99.9
alcohol use disorder measurement
4
8
99.5
0
1.6
99
alcohol dependence measurement
10
97.8
IGF-1 measurement
3
91.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:87921
11522
Dog
alcohol dehydrogenase E chain
100856533
Opossum
alcohol dehydrogenase S chain-like
100015889
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
alcohol dehydrogenase E chain
Opossum
alcohol dehydrogenase S chain-like
Publication Statistics
PubMed Score 482.79
PubMed score by year
PubTator Score 189.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title