Tbio ADGRV1 Adhesion G-protein coupled receptor V1

Protein Summary

Description

G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing the stability of this protein in myelin-forming cells of the auditory pathway. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Involved in the regulation of bone metabolism. Cleaved ADGRV1 beta-subunit couples with G-alpha(i)-proteins, GNAI1/2/3, and constitutively inhibits adenylate cyclase (AC) activity with a stronger effect than full ADGRV1. This gene encodes a member of the G-protein coupled receptor superfamily. The encoded protein contains a 7-transmembrane receptor domain, binds calcium and is expressed in the central nervous system. Mutations in this gene are associated with Usher syndrome 2 and familial febrile seizures. Several alternatively spliced transcripts have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8WXG9
• O75171
• Q8TF58
• Q9H0X5
• Q9UL61
• ADGRV1

Gene Name

• ADGRV1

Ensembl ID

• ENST00000405460
• ENSP00000384582
• ENSG00000164199
• ENST00000645211
• ENSP00000495777

Symbol

• GPR98
• KIAA0686
• KIAA1943
• MASS1
• VLGR1
• FEB4
• GPR98
• MASS1
• USH2B
• USH2C
• VLGR1
• VLGR1b

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.99
protein domain	0.97
cellular component	0.78
gene perturbation	0.74
transcription factor perturbation	0.68

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Adhesion Class / G-protein Coupled Receptor 98

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.02   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 111   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.02   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0