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Tbio
ADGRL2
Adhesion G protein-coupled receptor L2

Protein Summary
Description
Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319517
  • ENSP00000322270
  • ENSG00000117114
  • ENST00000359929
  • ENSP00000353006
  • ENST00000370713
  • ENSP00000359748
  • ENST00000370715
  • ENSP00000359750
  • ENST00000370717
  • ENSP00000359752
  • ENST00000370723
  • ENSP00000359758
  • ENST00000370725
  • ENSP00000359760
  • ENST00000370728
  • ENSP00000359763
  • ENST00000370730
  • ENSP00000359765

Symbol
  • KIAA0786
  • LEC1
  • LPHH1
  • LPHN2
  • CL2
  • LEC1
  • CIRL2
  • LPHH1
  • LPHN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
0.93
disease perturbation
0.83
PubMedID
0.82
microRNA
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.92   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.92   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0