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Tbio
ADGRL2
Adhesion G protein-coupled receptor L2

Protein Summary
Description
Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319517
  • ENSP00000322270
  • ENSG00000117114
  • ENST00000359929
  • ENSP00000353006
  • ENST00000370713
  • ENSP00000359748
  • ENST00000370715
  • ENSP00000359750
  • ENST00000370717
  • ENSP00000359752
  • ENST00000370723
  • ENSP00000359758
  • ENST00000370725
  • ENSP00000359760
  • ENST00000370728
  • ENSP00000359763
  • ENST00000370730
  • ENSP00000359765

Symbol
  • KIAA0786
  • LEC1
  • LPHH1
  • LPHN2
  • CL2
  • LEC1
  • CIRL2
  • LPHH1
  • LPHN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
0.93
disease perturbation
0.83
PubMedID
0.82
microRNA
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.6   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.6   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (216)
FLRT1
Tdark
Novelty:  0.23047852
p_int:  0.941030828
p_ni:  0.058969172
Score:  0.811
Data Source:  BioPlex,STRINGDB
LPCAT2
Tbio
Family:  Enzyme
Novelty:  0.02794035
p_int:  0.864349409
p_ni:  0.135650591
Data Source:  BioPlex
TMPRSS11B
Tdark
Family:  Enzyme
Novelty:  1.20690443
p_int:  0.8327849
p_ni:  0.167215085
p_wrong:  1.6e-8
Data Source:  BioPlex
FLRT3
Tbio
Novelty:  0.05467656
Score:  0.902
Data Source:  STRINGDB
MGAT1
Tchem
Family:  Enzyme
Novelty:  0.01024931
Score:  0.871
Data Source:  STRINGDB
FLRT2
Tbio
Novelty:  0.08424771
Score:  0.838
Data Source:  STRINGDB
LRRC15
Tbio
Novelty:  0.03701624
Score:  0.765
Data Source:  STRINGDB
ADGRA3
Tbio
Family:  GPCR
Novelty:  0.06798451
Score:  0.757
Data Source:  STRINGDB
ADGRA1
Tbio
Family:  GPCR
Novelty:  0.24926468
Score:  0.752
Data Source:  STRINGDB
EPYC
Tbio
Novelty:  0.01215969
Score:  0.752
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
3
4
75.7
chin morphology measurement
1
1
0
1.2
58.4
intelligence
1
1
1
33.1
serum gamma-glutamyl transferase measurement
1
1
1
31.4
body height
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
75.7
chin morphology measurement
0
1.2
58.4
intelligence
1
33.1
serum gamma-glutamyl transferase measurement
1
31.4
body height
1
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor L2
VGNC:43
456974
Macaque
adhesion G protein-coupled receptor L2
708998
Dog
adhesion G protein-coupled receptor L2
VGNC:37651
490193
Horse
adhesion G protein-coupled receptor L2
VGNC:15113
100052932
Cow
adhesion G protein-coupled receptor L2
VGNC:53846
281278
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor L2
Macaque
adhesion G protein-coupled receptor L2
Dog
adhesion G protein-coupled receptor L2
Horse
adhesion G protein-coupled receptor L2
Cow
adhesion G protein-coupled receptor L2
Publication Statistics
PubMed Score 107.60
PubMed score by year
PubTator Score 35.29
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title