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Tbio
ADGRL1
Adhesion G protein-coupled receptor L1

Protein Summary
Description
Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340736
  • ENSP00000340688
  • ENSG00000072071
  • ENST00000361434
  • ENSP00000355328

Symbol
  • KIAA0821
  • LEC2
  • LPHN1
  • CL1
  • LEC2
  • CIRL1
  • LPHN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.98
transcription factor perturbation
0.74
kinase perturbation
0.71
tissue sample
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.73   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.73   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (255)
FLRT1
Tdark
Novelty:  0.23047852
p_int:  0.999487427
p_ni:  0.000512573
Score:  0.851
Data Source:  BioPlex,STRINGDB
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.9981169
p_ni:  0.0018831
Data Source:  BioPlex
PCDHGB1
Tdark
Novelty:  0.60440805
p_int:  0.997211711
p_ni:  0.002788289
Data Source:  BioPlex
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.996928846
p_ni:  0.003071153
p_wrong:  1e-9
Data Source:  BioPlex
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.993992666
p_ni:  0.006007334
Score:  0.182
Data Source:  BioPlex,STRINGDB
LPCAT2
Tbio
Family:  Enzyme
Novelty:  0.02794035
p_int:  0.984717813
p_ni:  0.015282168
p_wrong:  1.9e-8
Data Source:  BioPlex
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.980116827
p_ni:  0.019883173
Data Source:  BioPlex
B4GAT1
Tbio
Family:  Enzyme
Novelty:  0.14959923
p_int:  0.979369926
p_ni:  0.020630074
Data Source:  BioPlex
FAM189A2
Tdark
Novelty:  0.41335428
p_int:  0.968211987
p_ni:  0.031788009
p_wrong:  5e-9
Data Source:  BioPlex
NRG1
Tbio
Novelty:  0.00095246
p_int:  0.968064349
p_ni:  0.031935574
p_wrong:  7.7e-8
Score:  0.162
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
2
2
56.6
sex hormone-binding globulin measurement
2
1
2
40.4
serum gamma-glutamyl transferase measurement
2
1
2
31.1
red blood cell density measurement
1
1
1
15.8
testosterone measurement
1
1
1
15.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
56.6
sex hormone-binding globulin measurement
2
40.4
serum gamma-glutamyl transferase measurement
2
31.1
red blood cell density measurement
1
15.8
testosterone measurement
1
15.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor L1
VGNC:6609
455777
Macaque
adhesion G protein-coupled receptor L1
718708
Mouse
MGI:1929461
330814
Rat
RGD:620768
65096
Dog
adhesion G protein-coupled receptor L1
VGNC:37650
610349
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor L1
Macaque
adhesion G protein-coupled receptor L1
Mouse
Rat
Dog
adhesion G protein-coupled receptor L1
Publication Statistics
PubMed Score 106.73
PubMed score by year
PubTator Score 196.70
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title