Tbio ADGRF5 Adhesion G protein-coupled receptor F5

Protein Summary

Description

Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function.

Uniprot Accession IDs

• Q8IZF2
• O94858
• Q5TF06
• Q6RGN2
• Q86SP0
• Q9Y3Z2

Gene Name

• ADGRF5

Ensembl ID

• ENST00000265417
• ENSP00000265417
• ENSG00000069122
• ENST00000283296
• ENSP00000283296

Symbol

• GPR116
• KIAA0758
• GPR116
• KPG_001

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
cell type or tissue	0.83
transcription factor perturbation	0.74
PubMedID	0.68
phenotype	0.63

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Adhesion Class / Adhesion G Protein-coupled Receptor F5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.34   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 221   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.34   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0