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Tdark
ADGRF2
Adhesion G-protein coupled receptor F2

Protein Summary
Description
Orphan receptor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296862
  • ENSP00000296862
  • ENSG00000164393
  • ENST00000398742
  • ENSP00000381727
  • ENST00000467205
  • ENSP00000425269

Symbol
  • GPR111
  • PGR20
  • PGR20
  • GPR111
  • hGPCR35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.63
disease
0.57
phenotype
0.54
cell line
0.52
chemical
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.88   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.88   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (21)
LRRC46
Tdark
Novelty:  1.159245
Score:  0.822
Data Source:  STRINGDB
GPR141
Tdark
Family:  GPCR
Novelty:  0.30711523
Score:  0.726
Data Source:  STRINGDB
GPR139
Tchem
Family:  GPCR
Novelty:  0.04083224
Score:  0.726
Data Source:  STRINGDB
GPR148
Tbio
Family:  GPCR
Novelty:  0.019374
Score:  0.697
Data Source:  STRINGDB
ADGRA1
Tbio
Family:  GPCR
Novelty:  0.24926468
Score:  0.691
Data Source:  STRINGDB
ADGRA3
Tbio
Family:  GPCR
Novelty:  0.06798451
Score:  0.668
Data Source:  STRINGDB
MCCD1
Tdark
Novelty:  0.55621159
Score:  0.657
Data Source:  STRINGDB
ADGRA2
Tbio
Family:  GPCR
Novelty:  0.02854335
Score:  0.636
Data Source:  STRINGDB
PPRC1
Tbio
Novelty:  0.00182088
Score:  0.58
Data Source:  STRINGDB
PDZD7
Tbio
Novelty:  0.09467006
Score:  0.576
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
3
3
80.4
mean platelet volume
3
2
3
76.9
red blood cell distribution width
1
1
1
53.6
mean corpuscular volume
1
1
1
43.2
homocysteine measurement
1
1
1
43.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
80.4
mean platelet volume
3
76.9
red blood cell distribution width
1
53.6
mean corpuscular volume
1
43.2
homocysteine measurement
1
43.2
Find similar targets by:
IDG Resources
Items per page:
10
1 – 10 of 20
Genetic Construct
pcDNA3.1-GGamma13-GFP2
image for pcDNA3.1-GGamma13-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma9-GFP2
image for pcDNA3.1-GGamma9-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma8-GFP2
image for pcDNA3.1-GGamma8-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma1-GFP2
image for pcDNA3.1-GGamma1-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-Beta3
image for pcDNA3.1-Beta3
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-Beta1
image for pcDNA3.1-Beta1
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA5/FRT/TO-GAlpha13-RLuc8
image for pcDNA5/FRT/TO-GAlpha13-RLuc8
Details:
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Genetic Construct
pcDNA5/FRT/TO-GAlpha12-RLuc8
image for pcDNA5/FRT/TO-GAlpha12-RLuc8
Details:
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Genetic Construct
pcDNA5/FRT/TO-GAlpha15-RLuc8
image for pcDNA5/FRT/TO-GAlpha15-RLuc8
Details:
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Genetic Construct
pcDNA5/FRT/TO-GAlpha11-RLuc8
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Details:
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Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2182728
435529
Rat
RGD:1306718
301269
Dog
adhesion G protein-coupled receptor F2
VGNC:37639
609995
Horse
adhesion G protein-coupled receptor F2
VGNC:15104
100068533
Cow
adhesion G protein-coupled receptor F2
VGNC:25662
539131
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
adhesion G protein-coupled receptor F2
Horse
adhesion G protein-coupled receptor F2
Cow
adhesion G protein-coupled receptor F2
Publication Statistics
PubMed Score 2.88
PubMed score by year
PubTator Score 1.88
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title