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Tbio
ADGRB2
Adhesion G protein-coupled receptor B2

Protein Summary
Description
Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ (PubMed:20367554, PubMed:28891236). Involved in angiogenesis inhibition (By similarity). This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373655
  • ENSP00000362759
  • ENSG00000121753
  • ENST00000373658
  • ENSP00000362762
  • ENST00000527361
  • ENSP00000435397

Symbol
  • BAI2
  • BAI2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
PubMedID
0.76
transcription factor
0.72
transcription factor binding site profile
0.72
disease perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.21   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.21   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
MAGI1
Tbio
Family:  Enzyme
Novelty:  0.06837323
Score:  0.651
Data Source:  STRINGDB
GPR137C
Tdark
Novelty:  3.30248948
Score:  0.581
Data Source:  STRINGDB
TMEM132E
Tdark
Novelty:  0.27039617
Score:  0.577
Data Source:  STRINGDB
TMEM212
Tdark
Novelty:  0.94290731
Score:  0.573
Data Source:  STRINGDB
TMEM211
Tdark
Novelty:  6.51386952
Score:  0.57
Data Source:  STRINGDB
TMEM221
Tdark
Novelty:  6.39119451
Score:  0.553
Data Source:  STRINGDB
RLF
Tdark
Novelty:  0.73853259
Score:  0.545
Data Source:  STRINGDB
RHOJ
Tbio
Family:  Enzyme
Novelty:  0.01217051
Score:  0.54
Data Source:  STRINGDB
DOCK1
Tbio
Novelty:  0.00867391
Score:  0.539
Data Source:  STRINGDB
KCNJ4
Tchem
Family:  IC
Novelty:  0.0093539
Score:  0.525
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
5
12
5
6
84.1
self reported educational attainment
3
3
2
6.1
75.4
cognitive function measurement
3
2
3
68.5
reticulocyte measurement
2
2
2
66.6
body mass index
2
2
2
61.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
5
6
84.1
self reported educational attainment
2
6.1
75.4
cognitive function measurement
3
68.5
reticulocyte measurement
2
66.6
body mass index
2
61.3
Find similar targets by:
IDG Resources
Mouse
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Details:
  • Allele:  Insertion
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor B2
VGNC:33
456703
Macaque
adhesion G protein-coupled receptor B2
706332
Mouse
MGI:2451244
230775
Rat
RGD:1309431
313058
Xenopus
adhesion G protein-coupled receptor B2
XB-GENE-956346
100498218
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor B2
Macaque
adhesion G protein-coupled receptor B2
Mouse
Rat
Xenopus
adhesion G protein-coupled receptor B2
Publication Statistics
PubMed Score 16.21
PubMed score by year
PubTator Score 11.23
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title