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Tbio
ADGRA2
Adhesion G protein-coupled receptor A2

Protein Summary
Description
Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315215
  • ENSP00000323508
  • ENSG00000020181
  • ENST00000412232
  • ENSP00000406367

Symbol
  • GPR124
  • KIAA1531
  • TEM5
  • TEM5
  • GPR124
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
gene perturbation
0.87
PubMedID
0.82
microRNA
0.76
transcription factor binding site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.87   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 297   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.87   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
ITGAV
Tchem
Novelty:  0.00148589
Score:  0.912
Data Source:  STRINGDB
ITGB3
Tclin
Novelty:  0.00067255
Score:  0.902
Data Source:  STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.755
Data Source:  STRINGDB
DLG1
Tbio
Novelty:  0.0050926
Score:  0.749
Data Source:  STRINGDB
ADGRL2
Tbio
Family:  GPCR
Novelty:  0.00985539
Score:  0.739
Data Source:  STRINGDB
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
Score:  0.728
Data Source:  STRINGDB
PLXDC1
Tbio
Novelty:  0.01025354
Score:  0.709
Data Source:  STRINGDB
ADGRF2
Tdark
Family:  GPCR
Novelty:  0.35622722
Score:  0.636
Data Source:  STRINGDB
NDP
Tbio
Novelty:  0.01020963
Score:  0.635
Data Source:  STRINGDB
CD248
Tbio
Novelty:  0.00063383
Score:  0.631
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor A2
VGNC:3024
472739
Macaque
adhesion G protein-coupled receptor A2
698629
Mouse
MGI:1925810
78560
Rat
RGD:2323365
100363275
Dog
adhesion G protein-coupled receptor A2
VGNC:37632
482853
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor A2
Macaque
adhesion G protein-coupled receptor A2
Mouse
Rat
Dog
adhesion G protein-coupled receptor A2
Publication Statistics
PubMed Score 43.87
PubMed score by year
PubTator Score 21.50
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title