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Tbio
ADGRA1
Adhesion G protein-coupled receptor A1

Protein Summary
Description
Orphan receptor. This gene encodes a protein that belongs to the adhesion family of G-protein-coupled receptors. Members of this family function in several sensory systems and regulate blood pressure, immune responses, food intake and development. A similar protein in rodents is thought to play a role in in the regulation of neuronal signaling pathways. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392606
  • ENSP00000376383
  • ENSG00000197177
  • ENST00000392607
  • ENSP00000376384
  • ENST00000607359
  • ENSP00000475778

Symbol
  • GPR123
  • KIAA1828
  • GPR123
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.59
cell line
0.55
cell type or tissue
0.42
tissue
0.42
chemical
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.8   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.8   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
SCTR
Tclin
Family:  GPCR
Novelty:  0.01163942
Score:  0.8
Data Source:  STRINGDB
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
Score:  0.795
Data Source:  STRINGDB
KNDC1
Tdark
Novelty:  0.1459108
Score:  0.77
Data Source:  STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.756
Data Source:  STRINGDB
ADGRL2
Tbio
Family:  GPCR
Novelty:  0.00985539
Score:  0.752
Data Source:  STRINGDB
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
Score:  0.741
Data Source:  STRINGDB
ADGRG7
Tbio
Family:  GPCR
Novelty:  0.19267741
Score:  0.73
Data Source:  STRINGDB
ADGRG3
Tchem
Family:  GPCR
Novelty:  0.11719468
Score:  0.724
Data Source:  STRINGDB
ADGRF3
Tdark
Family:  GPCR
Novelty:  0.45930903
Score:  0.723
Data Source:  STRINGDB
ADGRD2
Tdark
Family:  GPCR
Novelty:  1.00566581
Score:  0.705
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
38.8
testosterone measurement
1
1
1
28.1
multisite chronic pain
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
38.8
testosterone measurement
1
28.1
multisite chronic pain
1
15.8
Find similar targets by:
IDG Resources
Mouse
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Details:
  • Allele:  Insertion
Publication Statistics
PubMed Score 5.80
PubMed score by year
PubTator Score 3.36
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title