Tbio ADD2 Beta-adducin

Protein Summary

Description

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• P35612
• A8K4P2
• B4DM17
• D6W5G7
• D6W5G8
• Q13482
• Q16412
• Q59G82
• Q5U5P4
• Q6P0P2
• Q6PGQ4
• Q7Z688
• Q7Z689
• Q7Z690
• Q7Z691

Gene Name

• ADD2

Ensembl ID

• ENST00000264436
• ENSP00000264436
• ENSG00000075340
• ENST00000355733
• ENSP00000347972
• ENST00000403045
• ENSP00000384303
• ENST00000407644
• ENSP00000384677
• ENST00000413157
• ENSP00000388072
• ENST00000430656
• ENSP00000398112

Symbol

• ADDB
• ADDB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase	0.94
virus perturbation	0.83
hub protein	0.79
tissue sample	0.7
microRNA	0.68

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Beta-adducin

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Beta-adducin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.44   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.44   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0