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Tbio
ADCY9
Adenylate cyclase type 9

Protein Summary
Description
Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294016
  • ENSP00000294016
  • ENSG00000162104

Symbol
  • KIAA0520
  • AC9
  • ACIX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
transcription factor perturbation
0.96
biological process
0.95
molecular function
0.9
microRNA
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.64   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.64   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (518)
NEMP1
Tdark
Novelty:  0.37603456
p_int:  0.999999486
p_ni:  5.13e-7
p_wrong:  1e-9
Data Source:  BioPlex
AREG
Tchem
Novelty:  0.0017631
p_int:  0.999981853
p_ni:  0.000018145
p_wrong:  2e-9
Score:  0.233
Data Source:  BioPlex,STRINGDB
ANKMY2
Tdark
Novelty:  0.50777631
p_int:  0.999979597
p_ni:  0.000020403
Data Source:  BioPlex
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999947476
p_ni:  0.000052524
Data Source:  BioPlex
PIANP
Tbio
Novelty:  0.01739512
p_int:  0.999923809
p_ni:  0.000076191
Score:  0.169
Data Source:  BioPlex,STRINGDB
NLGN2
Tbio
Family:  Enzyme
Novelty:  0.01613168
p_int:  0.999825688
p_ni:  0.000174308
p_wrong:  4e-9
Data Source:  BioPlex
NLGN1
Tbio
Family:  Enzyme
Novelty:  0.0097512
p_int:  0.999812424
p_ni:  0.000187573
p_wrong:  3e-9
Data Source:  BioPlex
CLMN
Tbio
Novelty:  0.0822701
p_int:  0.999757303
p_ni:  0.000242384
p_wrong:  3.12e-7
Data Source:  BioPlex
FNDC3A
Tbio
Novelty:  0.04721453
p_int:  0.999583337
p_ni:  0.000416663
Data Source:  BioPlex
RPRM
Tbio
Novelty:  0.02938708
p_int:  0.999578935
p_ni:  0.000421062
p_wrong:  2e-9
Data Source:  BioPlex
Nearest Tclin Targets (35)
Explore Nearest Tclin Targets
Pathways (107)
Activation of GABAB receptors (R-HSA-991365)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of GABAB receptors
Reactome
Adenylate cyclase activating pathway
Reactome
Adenylate cyclase inhibitory pathway
Reactome
Aquaporin-mediated transport
Reactome
Ca-dependent events
Name
Explore in Pharos
Explore in Source
Activation of GABAB receptors
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
Aquaporin-mediated transport
Ca-dependent events
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
4
4
91.9
heel bone mineral density
3
4
5
91.8
body mass index
9
5
12
89.2
body height
2
2
2
87.6
lymphocyte count
3
2
3
82.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
91.9
heel bone mineral density
5
91.8
body mass index
12
89.2
body height
2
87.6
lymphocyte count
3
82.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenylate cyclase 9
VGNC:5667
453869
Mouse
MGI:108450
11515
Dog
adenylate cyclase 9
VGNC:37626
490031
Horse
adenylate cyclase 9
VGNC:15093
100066046
Cow
adenylate cyclase 9
VGNC:25650
525482
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenylate cyclase 9
Mouse
Dog
adenylate cyclase 9
Horse
adenylate cyclase 9
Cow
adenylate cyclase 9
Publication Statistics
PubMed Score 141.64
PubMed score by year
PubTator Score 47.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title