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Tchem
ADCY6
Adenylate cyclase type 6

Protein Summary
Description
Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to no ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307885
  • ENSP00000311405
  • ENSG00000174233
  • ENST00000357869
  • ENSP00000350536
  • ENST00000550422
  • ENSP00000446730

Symbol
  • KIAA0422
  • AC6
  • LCCS8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.95
disease perturbation
0.79
pathway
0.75
small molecule perturbation
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 239.49   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 239.49   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (483)
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999994706
p_ni:  0.000005294
Data Source:  BioPlex
NEUROG3
Tbio
Family:  TF
Novelty:  0.00341077
p_int:  0.998263373
p_ni:  0.001736627
Data Source:  BioPlex
B4GAT1
Tbio
Family:  Enzyme
Novelty:  0.14959923
p_int:  0.99816879
p_ni:  0.00183121
Data Source:  BioPlex
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.996853287
p_ni:  0.003146701
p_wrong:  1.2e-8
Data Source:  BioPlex
ANKMY2
Tdark
Novelty:  0.50777631
p_int:  0.996465395
p_ni:  0.003534427
p_wrong:  1.78e-7
Score:  0.242
Data Source:  BioPlex,STRINGDB
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.991189407
p_ni:  0.008810585
p_wrong:  7e-9
Data Source:  BioPlex
SYNE4
Tbio
Novelty:  0.0739848
p_int:  0.989123375
p_ni:  0.010875609
p_wrong:  0.000001016
Data Source:  BioPlex
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.987830143
p_ni:  0.012169636
p_wrong:  2.21e-7
Data Source:  BioPlex
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.981675538
p_ni:  0.01832413
p_wrong:  3.32e-7
Data Source:  BioPlex
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.96807185
p_ni:  0.031924958
p_wrong:  0.000003191
Data Source:  BioPlex
Nearest Tclin Targets (33)
Explore Nearest Tclin Targets
Pathways (111)
Activation of GABAB receptors (R-HSA-991365)

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Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of GABAB receptors
Reactome
Adenylate cyclase activating pathway
Reactome
Adenylate cyclase inhibitory pathway
Reactome
Adrenaline,noradrenaline inhibits insulin secretion
Reactome
Aquaporin-mediated transport
Name
Explore in Pharos
Explore in Source
Activation of GABAB receptors
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
Adrenaline,noradrenaline inhibits insulin secretion
Aquaporin-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
3
3
3
90.6
bone density
1
1
2
52.9
appendicular lean mass
1
1
1
40.4
leukocyte count
1
1
1
36
educational attainment
1
2
2
29.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
3
90.6
bone density
2
52.9
appendicular lean mass
1
40.4
leukocyte count
1
36
educational attainment
2
29.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenylate cyclase 6
VGNC:12756
451866
Macaque
adenylate cyclase 6
707978
Mouse
MGI:87917
11512
Rat
RGD:2035
25289
Dog
adenylate cyclase 6
VGNC:37623
477625
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenylate cyclase 6
Macaque
adenylate cyclase 6
Mouse
Rat
Dog
adenylate cyclase 6
Publication Statistics
PubMed Score 239.49
PubMed score by year
PubTator Score 52.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title