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Tbio
ADCY4
Adenylate cyclase type 4

Protein Summary
Description
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310677
  • ENSP00000312126
  • ENSG00000129467
  • ENST00000418030
  • ENSP00000393177
  • ENST00000554068
  • ENSP00000452250
  • ENST00000642645
  • ENSP00000495316
  • ENSG00000284814
  • ENST00000644961
  • ENSP00000494454
  • ENST00000646612
  • ENSP00000494977

Symbol
  • AC4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
molecular function
0.91
pathway
0.73
tissue sample
0.62
PubMedID
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.65   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.65   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0