You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ADCY3
Adenylate cyclase type 3

Protein Summary
Description
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260600
  • ENSP00000260600
  • ENSG00000138031

Symbol
  • KIAA0511
  • AC3
  • AC-III
  • BMIQ19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
co-expressed gene
0.96
molecular function
0.93
cell type or tissue
0.89
kinase perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 411.52   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 411.52   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (526)
ANKMY2
Tdark
Novelty:  0.50777631
p_int:  0.999995141
p_ni:  0.000004859
Score:  0.232
Data Source:  BioPlex,STRINGDB
SLC4A8
Tbio
Family:  Transporter
Novelty:  0.01606111
p_int:  0.998990486
p_ni:  0.001009512
p_wrong:  2e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
ASIC4
Tbio
Family:  IC
Novelty:  0.02912816
p_int:  0.998913445
p_ni:  0.001086553
p_wrong:  2e-9
Data Source:  BioPlex
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.998669634
p_ni:  0.001330358
p_wrong:  7e-9
Score:  0.905
Data Source:  BioPlex,STRINGDB
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.996493614
p_ni:  0.003475574
p_wrong:  0.000030811
Data Source:  BioPlex
CNGA3
Tchem
Family:  IC
Novelty:  0.00818181
p_int:  0.996491387
p_ni:  0.003484416
p_wrong:  0.000024198
Score:  0.376
Data Source:  BioPlex,STRINGDB
IL17RC
Tclin
Novelty:  0.01844832
p_int:  0.989974863
p_ni:  0.010023416
p_wrong:  0.00000172
Score:  0.172
Data Source:  BioPlex,STRINGDB
PCDHGA5
Tdark
Novelty:  2.13631603
p_int:  0.977077602
p_ni:  0.022918841
p_wrong:  0.000003558
Data Source:  BioPlex
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.964618805
p_ni:  0.033883702
p_wrong:  0.001497493
Data Source:  BioPlex
IZUMO1
Tbio
Novelty:  0.01839953
p_int:  0.954306154
p_ni:  0.045171519
p_wrong:  0.000522327
Data Source:  BioPlex
Nearest Tclin Targets (35)
Explore Nearest Tclin Targets
Pathways (107)
Activation of GABAB receptors (R-HSA-991365)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of GABAB receptors
Reactome
Adenylate cyclase activating pathway
Reactome
Adenylate cyclase inhibitory pathway
Reactome
Aquaporin-mediated transport
Reactome
Ca-dependent events
Name
Explore in Pharos
Explore in Source
Activation of GABAB receptors
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
Aquaporin-mediated transport
Ca-dependent events
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
28
10
40
3.3
99.1
body height
5
5
6
96.9
waist-hip ratio
3
3
3
89.6
2
2
0
1.1
84.7
body fat distribution
2
1
4
82.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
40
3.3
99.1
body height
6
96.9
waist-hip ratio
3
89.6
0
1.1
84.7
body fat distribution
4
82.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenylate cyclase 3
VGNC:7
459070
Macaque
adenylate cyclase 3
693523
Mouse
MGI:99675
104111
Rat
RGD:71009
64508
Dog
adenylate cyclase 3
VGNC:37620
482994
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenylate cyclase 3
Macaque
adenylate cyclase 3
Mouse
Rat
Dog
adenylate cyclase 3
Publication Statistics
PubMed Score 411.52
PubMed score by year
PubTator Score 91.34
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title