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Tdark
ADCK5
Uncharacterized aarF domain-containing protein kinase 5

Protein Summary
Description
The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308860
  • ENSP00000310547
  • ENSG00000173137
  • ENST00000645968
  • ENSP00000494807
  • ENSG00000285451
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
transcription factor binding site profile
0.76
kinase perturbation
0.6
transcription factor
0.59
virus perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.25   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.25   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
FBXL6
Tdark
Novelty:  0.33416595
Score:  0.761
Data Source:  STRINGDB
TMEM249
Tdark
Novelty:  11.31914894
Score:  0.731
Data Source:  STRINGDB
EML3
Tdark
Novelty:  0.26210133
Score:  0.722
Data Source:  STRINGDB
MROH1
Tdark
Novelty:  1.16904275
Score:  0.707
Data Source:  STRINGDB
WDR97
Tdark
Novelty:  11.62556618
Score:  0.697
Data Source:  STRINGDB
SLC52A2
Tbio
Family:  Transporter
Novelty:  0.02484047
Score:  0.65
Data Source:  STRINGDB
COQ3
Tbio
Family:  Enzyme
Novelty:  0.03013258
Score:  0.62
Data Source:  STRINGDB
GPAA1
Tbio
Novelty:  0.01874575
Score:  0.613
Data Source:  STRINGDB
MKLN1
Tbio
Novelty:  0.05014385
Score:  0.595
Data Source:  STRINGDB
PPP1R16A
Tdark
Family:  Enzyme
Novelty:  0.1958289
Score:  0.571
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
2
3
3
41.3
93.6
alkaline phosphatase measurement
2
2
1
8
92.6
mathematical ability
4
4
4
92.4
self reported educational attainment
3
2
3
90.9
type 2 diabetes mellitus
3
3
2
1.1
90.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
3
41.3
93.6
alkaline phosphatase measurement
1
8
92.6
mathematical ability
4
92.4
self reported educational attainment
3
90.9
type 2 diabetes mellitus
2
1.1
90.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aarF domain containing kinase 5
VGNC:924
107976474
Macaque
aarF domain containing kinase 5
100425836
Mouse
MGI:2679274
268822
Rat
RGD:1305504
362943
Dog
aarF domain containing kinase 5
VGNC:37617
482095
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aarF domain containing kinase 5
Macaque
aarF domain containing kinase 5
Mouse
Rat
Dog
aarF domain containing kinase 5
Publication Statistics
PubMed Score 1.25
PubMed score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title