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Tbio
ADCK2
Uncharacterized aarF domain-containing protein kinase 2

Protein Summary
Description
The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000072869
  • ENSP00000072869
  • ENSG00000133597

Symbol
  • AARF
  • AARF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
cell type or tissue
0.72
histone modification site profile
0.72
cell line
0.56
tissue sample
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.1   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.1   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
PTCHD3
Tbio
Novelty:  0.00081643
p_int:  0.999953872
p_ni:  0.000046127
p_wrong:  1e-9
Data Source:  BioPlex
SLC4A8
Tbio
Family:  Transporter
Novelty:  0.01606111
p_int:  0.999568372
p_ni:  0.000431626
p_wrong:  2e-9
Score:  0.203
Data Source:  BioPlex,STRINGDB
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.999172143
p_ni:  0.000827856
p_wrong:  1e-9
Data Source:  BioPlex
PCDHGC5
Tdark
Novelty:  0.39651826
p_int:  0.997372952
p_ni:  0.002517048
p_wrong:  0.00011
Data Source:  BioPlex
KCNA5
Tclin
Family:  IC
Novelty:  0.00182891
p_int:  0.99719387
p_ni:  0.002597366
p_wrong:  0.000208764
Score:  0.185
Data Source:  BioPlex,STRINGDB
IL17RC
Tclin
Novelty:  0.01844832
p_int:  0.9936562
p_ni:  0.006337423
p_wrong:  0.000006377
Data Source:  BioPlex
LRRC8B
Tbio
Novelty:  0.16457267
p_int:  0.917108968
p_ni:  0.002530514
p_wrong:  0.080360517
Score:  0.173
Data Source:  BioPlex,STRINGDB
NMUR2
Tchem
Family:  GPCR
Novelty:  0.01353039
p_int:  0.86451223
p_ni:  0.005746006
p_wrong:  0.129741763
Score:  0.163
Data Source:  BioPlex,STRINGDB
TMCO3
Tdark
Novelty:  1.16719823
p_int:  0.86451223
p_ni:  0.005746006
p_wrong:  0.129741763
Score:  0.153
Data Source:  BioPlex,STRINGDB
COQ3
Tbio
Family:  Enzyme
Novelty:  0.03013258
Score:  0.772
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aarF domain containing kinase 2
VGNC:4248
463779
Macaque
aarF domain containing kinase 2
693303
Mouse
MGI:1889336
57869
Rat
RGD:1311058
312258
Dog
aarF domain containing kinase 2
VGNC:37616
475527
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aarF domain containing kinase 2
Macaque
aarF domain containing kinase 2
Mouse
Rat
Dog
aarF domain containing kinase 2
Publication Statistics
PubMed Score 7.10
PubMed score by year
PubTator Score 1.31
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title