Tbio ADAT3 Probable inactive tRNA-specific adenosine deaminase-like protein 3

Protein Summary

Description

This gene encodes a subunit of a tRNA-specific adenosine deaminase. This heterodimeric enzyme converts adenosine to inosine in the tRNA anticodon. A mutation in this gene causes a syndrome characterized by intellectual disability and strabismus. This gene shares its 5' exon with the overlapping gene, secretory carrier membrane protein 4 (Gene ID: 113178). [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q96EY9

Gene Name

• ADAT3

Ensembl ID

• ENST00000602400
• ENSP00000473571
• ENSG00000213638

Symbol

• TAD3
• TAD3
• MRT36
• FWP005
• MST121
• S863-5
• MSTP121

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.72
histone modification site profile	0.68
transcription factor perturbation	0.68
cell line	0.6
tissue sample	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.21   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.21   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0