Tbio ADAP1 Arf-GAP with dual PH domain-containing protein 1

Protein Summary

Description

GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).

Uniprot Accession IDs

• O75689
• A4D2Q2
• B3KRZ4
• B4DVA6
• F6XZ68
• H7C2Q4

Gene Name

• ADAP1

Ensembl ID

• ENST00000265846
• ENSP00000265846
• ENSG00000105963
• ENST00000449296
• ENSP00000407267
• ENST00000539900
• ENSP00000442682
• ENST00000611167
• ENSP00000481154

Symbol

• CENTA1
• GCS1L
• CENTA1
• p42IP4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.79
transcription factor binding site profile	0.66
tissue	0.57
interacting protein	0.52
tissue sample	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.22   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 210   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.22   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (56)

Explore Interacting Targets

1 – 10 of 56

• See Interactions on String-DB

KIF13B

Tbio

Novelty:  0.03817141

Score:  0.985

Data Source:  STRINGDB

ARF6

Tbio

Family:  Enzyme

Novelty:  0.00278138

Score:  0.976

Data Source:  STRINGDB

MYADML2

Tdark

Novelty:  1.43792271

Score:  0.747

Data Source:  STRINGDB

CNP

Tbio

Family:  Enzyme

Novelty:  0.00566142

Score:  0.723

Data Source:  STRINGDB

LMF1

Tbio

Family:  Enzyme

Novelty:  0.0280811

Score:  0.703

Data Source:  STRINGDB

COPS3

Tbio

Novelty:  0.04664225

Score:  0.692

Data Source:  STRINGDB

NCL

Tbio

Novelty:  0.00100905

Score:  0.675

Data Source:  STRINGDB

LRRC18

Tdark

Novelty:  1.02586195

Score:  0.647

Data Source:  STRINGDB

VSTM4

Tdark

Novelty:  0.46711608

Score:  0.625

Data Source:  STRINGDB

RASD1

Tbio

Family:  Enzyme

Novelty:  0.00533964

Score:  0.62

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (4)

PathwayCommons (2)

Nuclear signaling by ERBB4 (R-HSA-1251985)

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Find Similar Targets

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Nuclear signaling by ERBB4	32 targets	R-HSA-1251985
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by ERBB4	58 targets	R-HSA-1236394
Reactome	Signaling by Receptor Tyrosine Kinases	455 targets	R-HSA-9006934

Name	Explore in Pharos	Explore in Source
Nuclear signaling by ERBB4	32 targets	R-HSA-1251985
Signal Transduction	2704 targets	R-HSA-162582
Signaling by ERBB4	58 targets	R-HSA-1236394
Signaling by Receptor Tyrosine Kinases	455 targets	R-HSA-9006934

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (5)

Components (4)

Processes (2)

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Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
GTPase activator activity	Inferred from Direct Assay (IDA)	UniProtKB
inositol 1,3,4,5 tetrakisphosphate binding	Traceable Author Statement (TAS)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
phosphatidylinositol bisphosphate binding	Inferred from Electronic Annotation (IEA)	InterPro
phosphatidylinositol-3,4,5-trisphosphate binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (18)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 18

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
apolipoprotein A 1 measurement	EFO_0004614	2	3	3		90.1
high density lipoprotein cholesterol measurement	EFO_0004612	2	2	2		88.8
low density lipoprotein cholesterol measurement	EFO_0004611	4	3	4		87.3
total cholesterol measurement	EFO_0004574	3	3	3		86.8
C-reactive protein measurement	EFO_0004458	2	2	2		81.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 18

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
apolipoprotein A 1 measurement	EFO_0004614	3		90.1
high density lipoprotein cholesterol measurement	EFO_0004612	2		88.8
low density lipoprotein cholesterol measurement	EFO_0004611	4		87.3
total cholesterol measurement	EFO_0004574	3		86.8
C-reactive protein measurement	EFO_0004458	2		81.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
GTPase activation
Metal-binding
Nucleus
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
atrial fibrillation
C-reactive protein measurement
high density lipoprotein cholesterol measurement
IGF-1 measurement
insomnia measurement
low density lipoprotein cholesterol measurement
lymphocyte count
lymphocyte percentage of leukocytes
mean corpuscular volume

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	ArfGAP with dual PH domains 1		696246
Mouse	ArfGAP with dual PH domains 1	MGI:2442201	231821
Rat	ArfGAP with dual PH domains 1	RGD:621418	171097
Dog	ArfGAP with dual PH domains 1	VGNC:37610	606942
Horse	ArfGAP with dual PH domains 1	VGNC:51102	100630912

Species	Name	OMA	EggNOG	Inparanoid
Macaque	ArfGAP with dual PH domains 1
Mouse	ArfGAP with dual PH domains 1
Rat	ArfGAP with dual PH domains 1
Dog	ArfGAP with dual PH domains 1
Horse	ArfGAP with dual PH domains 1

Publication Statistics

PubMed Score 36.22

PubMed score by year

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PubTator Score 17.65

PubTator score by year

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Related Publications

Text Mined References (34)

GeneRif Annotations (18)

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PMID	Year	Title