Tbio ADAP1 Arf-GAP with dual PH domain-containing protein 1

Protein Summary

Description

GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).

Uniprot Accession IDs

• O75689
• A4D2Q2
• B3KRZ4
• B4DVA6
• F6XZ68
• H7C2Q4

Gene Name

• ADAP1

Ensembl ID

• ENST00000265846
• ENSP00000265846
• ENSG00000105963
• ENST00000449296
• ENSP00000407267
• ENST00000539900
• ENSP00000442682
• ENST00000611167
• ENSP00000481154

Symbol

• CENTA1
• GCS1L
• CENTA1
• p42IP4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.79
transcription factor binding site profile	0.66
tissue	0.57
interacting protein	0.52
tissue sample	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.41   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 210   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.41   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0