You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ADAMTSL4
ADAMTS-like protein 4

Protein Summary
Description
Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis. This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271643
  • ENSP00000271643
  • ENSG00000143382
  • ENST00000369038
  • ENSP00000358034
  • ENST00000369039
  • ENSP00000358035
  • ENST00000369041
  • ENSP00000358037

Symbol
  • TSRC1
  • TSRC1
  • ECTOL2
  • ADAMTSL-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.77
gene perturbation
0.74
histone modification site profile
0.65
transcription factor binding site profile
0.6
tissue sample
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.32   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.32   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
POFUT2
Tbio
Family:  Enzyme
Novelty:  0.06236603
Score:  0.958
Data Source:  STRINGDB
B3GLCT
Tbio
Family:  Enzyme
Novelty:  0.02398944
Score:  0.95
Data Source:  STRINGDB
ADAMTS10
Tbio
Family:  Enzyme
Novelty:  0.03532209
Score:  0.932
Data Source:  STRINGDB
ADAMTS17
Tbio
Family:  Enzyme
Novelty:  0.04568792
Score:  0.931
Data Source:  STRINGDB
ADAMTSL2
Tbio
Novelty:  0.05511648
Score:  0.928
Data Source:  STRINGDB
ADAMTSL5
Tbio
Novelty:  0.15248206
Score:  0.924
Data Source:  STRINGDB
ADAMTS2
Tbio
Family:  Enzyme
Novelty:  0.00852208
Score:  0.923
Data Source:  STRINGDB
ADAMTS20
Tbio
Family:  Enzyme
Novelty:  0.0416108
Score:  0.919
Data Source:  STRINGDB
ADAMTS4
Tchem
Family:  Enzyme
Novelty:  0.00424194
Score:  0.918
Data Source:  STRINGDB
ADAMTS13
Tbio
Family:  Enzyme
Novelty:  0.0006095
Score:  0.918
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (54)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
2
2
2
96.1
forced expiratory volume
2
2
2
93.2
chronotype measurement
2
2
1
1
90.4
blood protein measurement
5
4
5
89.5
monocyte percentage of leukocytes
2
4
4
88.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
2
96.1
forced expiratory volume
2
93.2
chronotype measurement
1
1
90.4
blood protein measurement
5
89.5
monocyte percentage of leukocytes
4
88.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAMTS like 4
VGNC:29
746960
Macaque
ADAMTS like 4
715768
Mouse
MGI:2389008
229595
Rat
RGD:1561012
310670
Dog
ADAMTS like 4
VGNC:37608
483184
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAMTS like 4
Macaque
ADAMTS like 4
Mouse
Rat
Dog
ADAMTS like 4
Publication Statistics
PubMed Score 34.32
PubMed score by year
PubTator Score 20.72
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title