You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ADAMTSL2
ADAMTS-like protein 2

Protein Summary
Description
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and ADAMTS-like protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene lacks the protease domain, and is therefore of a member of the the ADAMTS-like protein subfamily. It is a secreted glycoprotein that binds the cell surface and extracellular matrix; it also interacts with latent transforming growth factor beta binding protein 1. Mutations in this gene have been associated with geleophysic dysplasia. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354484
  • ENSP00000346478
  • ENSG00000197859
  • ENST00000393060
  • ENSP00000376780

Symbol
  • KIAA0605
  • GPHYSD1
  • ADAMTSL-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.72
transcription factor
0.63
tissue sample
0.61
protein domain
0.58
molecular function
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.75   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.75   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
POFUT2
Tbio
Family:  Enzyme
Novelty:  0.06236603
Score:  0.973
Data Source:  STRINGDB
B3GLCT
Tbio
Family:  Enzyme
Novelty:  0.02398944
Score:  0.955
Data Source:  STRINGDB
ADAMTS10
Tbio
Family:  Enzyme
Novelty:  0.03532209
Score:  0.938
Data Source:  STRINGDB
ADAMTSL1
Tbio
Novelty:  0.08853044
Score:  0.929
Data Source:  STRINGDB
ADAMTS17
Tbio
Family:  Enzyme
Novelty:  0.04568792
Score:  0.929
Data Source:  STRINGDB
ADAMTS2
Tbio
Family:  Enzyme
Novelty:  0.00852208
Score:  0.929
Data Source:  STRINGDB
ADAMTSL4
Tbio
Novelty:  0.03890484
Score:  0.928
Data Source:  STRINGDB
ADAMTS13
Tbio
Family:  Enzyme
Novelty:  0.0006095
Score:  0.928
Data Source:  STRINGDB
THBS1
Tchem
Novelty:  0.00073905
Score:  0.924
Data Source:  STRINGDB
ADAMTSL3
Tbio
Novelty:  0.07699522
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking cessation
3
6
8
99.2
cigarettes per day measurement
3
5
6
98.3
a disintegrin and metalloproteinase with thrombospondin motifs 13
1
2
0
5.3
97.1
ADAMTS13 activity measurement
1
1
0
21.7
94.2
diastolic blood pressure
3
2
3
91.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking cessation
8
99.2
cigarettes per day measurement
6
98.3
a disintegrin and metalloproteinase with thrombospondin motifs 13
0
5.3
97.1
ADAMTS13 activity measurement
0
21.7
94.2
diastolic blood pressure
3
91.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAMTS like 2
VGNC:4601
464962
Macaque
ADAMTS like 2
713492
Mouse
MGI:1925044
77794
Rat
RGD:1305459
311827
Dog
ADAMTS like 2
VGNC:37607
491276
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAMTS like 2
Macaque
ADAMTS like 2
Mouse
Rat
Dog
ADAMTS like 2
Publication Statistics
PubMed Score 28.75
PubMed score by year
PubTator Score 15.13
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title