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Tbio
ADAMTS9
A disintegrin and metalloproteinase with thrombospondin motifs 9

Protein Summary
Description
Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. Alterna ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295903
  • ENSP00000295903
  • ENSG00000163638
  • ENST00000498707
  • ENSP00000418735

Symbol
  • KIAA1312
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
protein domain
0.92
disease
0.76
cell line
0.66
microRNA
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.7   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.7   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
B3GLCT
Tbio
Family:  Enzyme
Novelty:  0.02398944
Score:  0.975
Data Source:  STRINGDB
ACAN
Tbio
Novelty:  0.00033695
Score:  0.954
Data Source:  STRINGDB
POFUT2
Tbio
Family:  Enzyme
Novelty:  0.06236603
Score:  0.938
Data Source:  STRINGDB
ADAMTSL1
Tbio
Novelty:  0.08853044
Score:  0.927
Data Source:  STRINGDB
ADAMTS12
Tbio
Family:  Enzyme
Novelty:  0.03184816
Score:  0.924
Data Source:  STRINGDB
ADAMTS13
Tbio
Family:  Enzyme
Novelty:  0.0006095
Score:  0.924
Data Source:  STRINGDB
ADAMTS3
Tbio
Family:  Enzyme
Novelty:  0.00578975
Score:  0.922
Data Source:  STRINGDB
ADAMTSL2
Tbio
Novelty:  0.05511648
Score:  0.921
Data Source:  STRINGDB
ADAMTS7
Tbio
Family:  Enzyme
Novelty:  0.02347655
Score:  0.92
Data Source:  STRINGDB
ADAMTS14
Tbio
Family:  Enzyme
Novelty:  0.07885034
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Degradation of the extracellular matrix
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Degradation of the extracellular matrix
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
12
29
47
99.5
waist-hip ratio
6
29
32
99.4
waist circumference
1
17
17
98.7
BMI-adjusted waist circumference
6
20
24
98.4
hip circumference
3
7
8
92.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
47
99.5
waist-hip ratio
32
99.4
waist circumference
17
98.7
BMI-adjusted waist circumference
24
98.4
hip circumference
8
92.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 9
VGNC:1988
473333
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 9
698341
Mouse
MGI:1916320
101401
Rat
RGD:1306889
312566
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 9
VGNC:37605
606847
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 9
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 9
Mouse
Rat
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 9
Publication Statistics
PubMed Score 77.70
PubMed score by year
PubTator Score 46.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title