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Tbio
ADAMTS8
A disintegrin and metalloproteinase with thrombospondin motifs 8

Protein Summary
Description
Has anti-angiogenic properties. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257359
  • ENSP00000257359
  • ENSG00000134917

Symbol
  • METH2
  • METH2
  • ADAM-TS8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
protein domain
0.92
PubMedID
0.65
gene perturbation
0.63
cell type or tissue
0.52


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.08   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.08   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
ACAN
Tbio
Novelty:  0.00033695
Score:  0.951
Data Source:  STRINGDB
THBS1
Tchem
Novelty:  0.00073905
Score:  0.93
Data Source:  STRINGDB
POFUT2
Tbio
Family:  Enzyme
Novelty:  0.06236603
Score:  0.928
Data Source:  STRINGDB
ADAMTSL2
Tbio
Novelty:  0.05511648
Score:  0.921
Data Source:  STRINGDB
ADAMTS13
Tbio
Family:  Enzyme
Novelty:  0.0006095
Score:  0.92
Data Source:  STRINGDB
ADAMTS19
Tbio
Family:  Enzyme
Novelty:  0.13082004
Score:  0.919
Data Source:  STRINGDB
ADAMTS10
Tbio
Family:  Enzyme
Novelty:  0.03532209
Score:  0.916
Data Source:  STRINGDB
ADAMTS14
Tbio
Family:  Enzyme
Novelty:  0.07885034
Score:  0.915
Data Source:  STRINGDB
ADAMTS17
Tbio
Family:  Enzyme
Novelty:  0.04568792
Score:  0.915
Data Source:  STRINGDB
ADAMTS3
Tbio
Family:  Enzyme
Novelty:  0.00578975
Score:  0.915
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Degradation of the extracellular matrix
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Degradation of the extracellular matrix
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal resistance factor
3
3
6
98.3
central corneal thickness
4
4
0
6
97.6
intraocular pressure measurement
2
3
3
96.2
cup-to-disc ratio measurement
4
2
5
95.2
corneal hysteresis
2
1
2
93.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal resistance factor
6
98.3
central corneal thickness
0
6
97.6
intraocular pressure measurement
3
96.2
cup-to-disc ratio measurement
5
95.2
corneal hysteresis
2
93.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 8
VGNC:3229
466852
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 8
718962
Mouse
MGI:1353468
30806
Rat
RGD:1308511
300475
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 8
VGNC:37604
100684302
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 8
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 8
Mouse
Rat
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 8
Publication Statistics
PubMed Score 33.08
PubMed score by year
PubTator Score 17.47
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title