You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
ADAMTS5
A disintegrin and metalloproteinase with thrombospondin motifs 5

Protein Summary
Description
Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its versican remodeling properties. Participates in development of brown adipose tissue and browning of white adipose tissue. Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, includi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284987
  • ENSP00000284987
  • ENSG00000154736

Symbol
  • ADAMTS11
  • ADMP2
  • ADMP-2
  • ADAM-TS5
  • ADAMTS-5
  • ADAMTS11
  • ADAM-TS 5
  • ADAMTS-11
  • ADAM-TS 11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
PubMedID
0.9
transcription factor perturbation
0.84
kinase perturbation
0.76
cell type or tissue
0.71


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.43   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 473   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.43   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 473   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 252
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0