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Tchem
ADAMTS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

Protein Summary
Description
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367996
  • ENSP00000356975
  • ENSG00000158859

Symbol
  • KIAA0688
  • ADMP-1
  • ADAMTS-2
  • ADAMTS-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor
0.75
biological term
0.73
gene perturbation
0.65
transcription factor perturbation
0.61


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.28   (req: < 5)
Gene RIFs: 90   (req: <= 3)
Antibodies: 548   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.28   (req: >= 5)
Gene RIFs: 90   (req: > 3)
Antibodies: 548   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 160
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (160)
Galardin
Rendered image for Galardin
CHEMBL187092
Rendered image for CHEMBL187092
CHEMBL79433
Rendered image for CHEMBL79433
CHEMBL366111
Rendered image for CHEMBL366111
CHEMBL1078281
Rendered image for CHEMBL1078281
US9206139, 2
Rendered image for US9206139, 2
CHEMBL4102193
Rendered image for CHEMBL4102193
CHEMBL179552
Rendered image for CHEMBL179552
CHEMBL4094455
Rendered image for CHEMBL4094455
Protein-Protein Interactions (155)
TFAP4
Tbio
Family:  TF
Novelty:  0.03155887
p_int:  0.999989096
p_ni:  0.000010904
Data Source:  BioPlex
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.99997741
p_ni:  0.00002259
Data Source:  BioPlex
CCDC33
Tdark
Novelty:  0.17166818
p_int:  0.999944877
p_ni:  0.000055123
Score:  0.182
Data Source:  BioPlex,STRINGDB
XIAP
Tchem
Family:  Enzyme
Novelty:  0.00062268
p_int:  0.999923226
p_ni:  0.000076774
Score:  0.215
Data Source:  BioPlex,STRINGDB
BIRC2
Tchem
Novelty:  0.00199701
p_int:  0.998111964
p_ni:  0.001887802
p_wrong:  2.34e-7
Data Source:  BioPlex
KIAA0232
Tdark
Novelty:  2.37569744
p_int:  0.993115454
p_ni:  0.006884433
p_wrong:  1.13e-7
Data Source:  BioPlex
DICER1
Tbio
Family:  Enzyme
Novelty:  0.000306
p_int:  0.991449089
p_ni:  0.008550911
Score:  0.158
Data Source:  BioPlex,STRINGDB
LOXL2
Tchem
Family:  Enzyme
Novelty:  0.00599536
p_int:  0.988005138
p_ni:  0.011985389
p_wrong:  0.000009472
Score:  0.161
Data Source:  BioPlex,STRINGDB
DPH6
Tbio
Family:  Enzyme
Novelty:  0.15211179
p_int:  0.961047947
p_ni:  0.006112592
p_wrong:  0.032839461
Score:  0.522
Data Source:  BioPlex,STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.957023735
p_ni:  0.042976265
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Degradation of the extracellular matrix
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Degradation of the extracellular matrix
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
1
4
4
93.7
blood protein measurement
1
4
4
93.4
mean platelet volume
3
2
4
93
blood metabolite measurement
2
2
2
83
4
2
0
1.1
82.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
4
93.7
blood protein measurement
4
93.4
mean platelet volume
4
93
blood metabolite measurement
2
83
0
1.1
82.8
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IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 4
VGNC:44
457453
Mouse
MGI:1339949
240913
Rat
RGD:621242
66015
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 4
VGNC:37600
488651
Horse
ADAM metallopeptidase with thrombospondin type 1 motif 4
VGNC:15070
100033914
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 4
Mouse
Rat
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 4
Horse
ADAM metallopeptidase with thrombospondin type 1 motif 4
Publication Statistics
PubMed Score 226.28
PubMed score by year
PubTator Score 198.09
PubTator score by year
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Related Publications
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PMID
Year
Title