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Tbio
ADAMTS3
A disintegrin and metalloproteinase with thrombospondin motifs 3

Protein Summary
Description
Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286657
  • ENSP00000286657
  • ENSG00000156140
  • ENST00000622135
  • ENSP00000480055

Symbol
  • KIAA0366
  • HKLLS3
  • ADAMTS-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.81
molecular function
0.7
transcription factor perturbation
0.68
microRNA
0.63


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.94   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.94   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
COL2A1
Tbio
Novelty:  0.0011102
Score:  0.965
Data Source:  STRINGDB
COL1A1
Tbio
Novelty:  0.00063584
Score:  0.943
Data Source:  STRINGDB
COL5A3
Tbio
Novelty:  0.06365591
Score:  0.94
Data Source:  STRINGDB
COL11A1
Tbio
Novelty:  0.00594683
Score:  0.929
Data Source:  STRINGDB
COL3A1
Tbio
Novelty:  0.00197327
Score:  0.926
Data Source:  STRINGDB
COL1A2
Tbio
Novelty:  0.00048334
Score:  0.925
Data Source:  STRINGDB
ADAMTS5
Tchem
Family:  Enzyme
Novelty:  0.00364004
Score:  0.923
Data Source:  STRINGDB
ADAMTS9
Tbio
Family:  Enzyme
Novelty:  0.01447959
Score:  0.922
Data Source:  STRINGDB
ADAMTS7
Tbio
Family:  Enzyme
Novelty:  0.02347655
Score:  0.922
Data Source:  STRINGDB
ADAMTS1
Tchem
Family:  Enzyme
Novelty:  0.00483758
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen formation
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen formation
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
11
11
98.9
BMI-adjusted hip circumference
3
8
8
90.3
BMI-adjusted waist circumference
5
6
7
88.4
low density lipoprotein cholesterol measurement
4
4
10
81.9
body height
5
5
7
81.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
11
98.9
BMI-adjusted hip circumference
8
90.3
BMI-adjusted waist circumference
7
88.4
low density lipoprotein cholesterol measurement
10
81.9
body height
7
81.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 3
VGNC:564
461267
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 3
705473
Mouse
MGI:3045353
330119
Rat
RGD:1310750
305253
Horse
A disintegrin and metalloproteinase with thrombospondin motifs 3
100050106
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 3
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 3
Mouse
Rat
Horse
A disintegrin and metalloproteinase with thrombospondin motifs 3
Publication Statistics
PubMed Score 151.94
PubMed score by year
PubTator Score 13.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title