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Tbio
ADAMTS20
A disintegrin and metalloproteinase with thrombospondin motifs 20

Protein Summary
Description
May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain. The protein encoded by this gene is a member of the ADAMTS family of zinc-dependent proteases. The encoded protein has a signal peptide that is cleaved to release the mature peptide, which is secreted and found in the extracellular matrix. This protein may be involved in tissue remodeling. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389420
  • ENSP00000374071
  • ENSG00000173157

Symbol
  • GON-1
  • ADAM-TS20
  • ADAMTS-20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.81
cell line
0.71
tissue sample
0.66
histone modification site profile
0.63


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.99   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 24   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.99   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
ADAMTSL1
Tbio
Novelty:  0.08853044
Score:  0.925
Data Source:  STRINGDB
B3GLCT
Tbio
Family:  Enzyme
Novelty:  0.02398944
Score:  0.924
Data Source:  STRINGDB
ADAMTSL3
Tbio
Novelty:  0.07699522
Score:  0.923
Data Source:  STRINGDB
ADAMTS19
Tbio
Family:  Enzyme
Novelty:  0.13082004
Score:  0.923
Data Source:  STRINGDB
ADAMTS13
Tbio
Family:  Enzyme
Novelty:  0.0006095
Score:  0.923
Data Source:  STRINGDB
ADAMTS14
Tbio
Family:  Enzyme
Novelty:  0.07885034
Score:  0.922
Data Source:  STRINGDB
POFUT2
Tbio
Family:  Enzyme
Novelty:  0.06236603
Score:  0.921
Data Source:  STRINGDB
ADAMTSL2
Tbio
Novelty:  0.05511648
Score:  0.921
Data Source:  STRINGDB
ADAMTS7
Tbio
Family:  Enzyme
Novelty:  0.02347655
Score:  0.921
Data Source:  STRINGDB
ADAMTS12
Tbio
Family:  Enzyme
Novelty:  0.03184816
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain measurement
1
1
0
16.2
25.8
cortical surface area measurement
1
1
0
8.8
13.2
corneal resistance factor
1
1
1
12.8
cortical thickness
1
1
0
7
7.2
central corneal thickness
1
1
0
1.8
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain measurement
0
16.2
25.8
cortical surface area measurement
0
8.8
13.2
corneal resistance factor
1
12.8
cortical thickness
0
7
7.2
central corneal thickness
0
1.8
6.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 20
VGNC:8314
451839
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 20
699935
Mouse
MGI:2660628
223838
Rat
RGD:1307725
315263
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 20
VGNC:37599
486602
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 20
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 20
Mouse
Rat
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 20
Publication Statistics
PubMed Score 32.99
PubMed score by year
PubTator Score 6.92
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title