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Tbio
ADAMTS2
A disintegrin and metalloproteinase with thrombospondin motifs 2

Protein Summary
Description
Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature procollagen N-proteinase. This proteinase excises the N-propeptide of the fibrillar procollagens types I-III and type V. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcrip ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251582
  • ENSP00000251582
  • ENSG00000087116
  • ENST00000274609
  • ENSP00000274609
  • ENST00000639107
  • ENSP00000492365
  • ENSG00000283802
  • ENST00000639986
  • ENSP00000492346

Symbol
  • PCINP
  • PCPNI
  • NPI
  • PNPI
  • PCINP
  • PCPNI
  • PCI-NP
  • PC I-NP
  • ADAM-TS2
  • ADAMTS-2
  • ADAMTS-3
  • EDSDERMS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
PubMedID
0.8
transcription factor perturbation
0.74
transcription factor
0.64
tissue sample
0.62


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 506.21   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 506.21   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0