Tbio ADAMTS14 A disintegrin and metalloproteinase with thrombospondin motifs 14

Protein Summary

Description

Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. [provided by RefSeq, May 2016]

Uniprot Accession IDs

• Q8WXS8
• Q5T4G0
• Q5T4G1
• Q8TE55
• Q8TEY8
• ADAM-TS 14

Gene Name

• ADAMTS14

Ensembl ID

• ENST00000373207
• ENSP00000362303
• ENSG00000138316
• ENST00000373208
• ENSP00000362304

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
histone modification site profile	0.67
cell line	0.64
phenotype	0.61
trait	0.61

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Metalloprotease / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 14

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 14

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 14

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 14

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.48   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 35   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.48   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0