Tbio ADAMTS13 A disintegrin and metalloproteinase with thrombospondin motifs 13

Protein Summary

Description

Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q76LX8
• Q6UY16
• Q710F6
• Q711T8
• Q96L37
• Q9H0G3
• Q9UGQ1
• ADAM-TS 13

Gene Name

• ADAMTS13

Ensembl ID

• ENST00000355699
• ENSP00000347927
• ENSG00000160323
• ENST00000356589
• ENSP00000348997
• ENST00000371929
• ENSP00000360997
• ENST00000626597
• ENSP00000486201
• ENSG00000281244
• ENST00000626744
• ENSP00000486734
• ENST00000630465
• ENSP00000485989

Symbol

• C9orf8
• VWFCP
• C9orf8
• vWF-CP
• ADAM-TS13
• ADAMTS-13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
molecular function	0.73
protein domain	0.73
tissue sample	0.71
cellular component	0.59

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Metalloprotease / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 13

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 13

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 13

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 13

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2112   (req: < 5)

Gene RIFs: 389   (req: <= 3)

Antibodies: 339   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2112   (req: >= 5)

Gene RIFs: 389   (req: > 3)

Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0