ADAMTS13
A disintegrin and metalloproteinase with thrombospondin motifs 13
Protein Summary
Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- ENST00000355699
- ENSP00000347927
- ENSG00000160323
- ENST00000356589
- ENSP00000348997
- ENST00000371929
- ENSP00000360997
- ENST00000626597
- ENSP00000486201
- ENSG00000281244
- ENST00000626744
- ENSP00000486734
- ENST00000630465
- ENSP00000485989
- C9orf8
- VWFCP
- C9orf8
- vWF-CP
- ADAM-TS13
- ADAMTS-13
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
molecular function | 0.73 | ||
protein domain | 0.73 | ||
tissue sample | 0.71 | ||
cellular component | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2112 (req: < 5)
Gene RIFs: 497 (req: <= 3)
Antibodies: 339 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2112 (req: >= 5)
Gene RIFs: 497 (req: > 3)
Antibodies: 339 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0