ADAMTS13
A disintegrin and metalloproteinase with thrombospondin motifs 13
Protein Summary
Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- ENST00000355699
- ENSP00000347927
- ENSG00000160323
- ENST00000356589
- ENSP00000348997
- ENST00000371929
- ENSP00000360997
- ENST00000626597
- ENSP00000486201
- ENSG00000281244
- ENST00000626744
- ENSP00000486734
- ENST00000630465
- ENSP00000485989
- C9orf8
- VWFCP
- C9orf8
- vWF-CP
- ADAM-TS13
- ADAMTS-13
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
molecular function | 0.73 | ||
protein domain | 0.73 | ||
tissue sample | 0.71 | ||
cellular component | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1862.44 (req: < 5)
Gene RIFs: 389 (req: <= 3)
Antibodies: 339 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1862.44 (req: >= 5)
Gene RIFs: 389 (req: > 3)
Antibodies: 339 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (105)
Nearest Tclin Targets
Pathways (48)
Reactome (8)
WikiPathways (40)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with O-glycosylation of proteins | ||||
Reactome | Diseases of glycosylation | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Disease | ||||
Diseases associated with O-glycosylation of proteins | ||||
Diseases of glycosylation | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (5)
Components (4)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
total cholesterol measurement | 1 | 5 | 5 | 96.8 | ||||||
total cholesterol measurement | 1 | 5 | 5 | 96.8 | ||||||
a disintegrin and metalloproteinase with thrombospondin motifs 13 | 1 | 3 | 0 | 7.1 | 96.4 | |||||
a disintegrin and metalloproteinase with thrombospondin motifs 13 | 1 | 3 | 0 | 7.1 | 96.4 | |||||
low density lipoprotein cholesterol measurement | 1 | 4 | 4 | 95.7 | ||||||
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
total cholesterol measurement | 5 | 96.8 | |||||
total cholesterol measurement | 5 | 96.8 | |||||
a disintegrin and metalloproteinase with thrombospondin motifs 13 | 0 | 7.1 | 96.4 | ||||
a disintegrin and metalloproteinase with thrombospondin motifs 13 | 0 | 7.1 | 96.4 | ||||
low density lipoprotein cholesterol measurement | 4 | 95.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ADAM metallopeptidase with thrombospondin type 1 motif 13 | VGNC:50888 | 473153 | |||||
Macaque | ADAM metallopeptidase with thrombospondin type 1 motif 13 | 722202 | ||||||
Mouse | MGI:2685556 | 279028 | ||||||
Rat | RGD:1311594 | 102554393 | ||||||
Dog | ADAM metallopeptidase with thrombospondin type 1 motif 13 | VGNC:37592 | 100630922 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ADAM metallopeptidase with thrombospondin type 1 motif 13 | |||||
Macaque | ADAM metallopeptidase with thrombospondin type 1 motif 13 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ADAM metallopeptidase with thrombospondin type 1 motif 13 | |||||
Publication Statistics
PubMed Score 1862.44
PubMed score by year
PubTator Score 1546.79
PubTator score by year
Related Publications
Text Mined References (422)
GeneRif Annotations (389)
Items per page:
0 of 0
PMID | Year | Title |
|---|