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Tbio
ADAMTS10
A disintegrin and metalloproteinase with thrombospondin motifs 10

Protein Summary
Description
Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues. This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000595838
  • ENSP00000470501
  • ENSG00000142303

Symbol
  • WMS
  • WMS1
  • ADAM-TS10
  • ADAMTS-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
tissue sample
0.62
histone modification site profile
0.55
cell type or tissue
0.53
interacting protein
0.53


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.77   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.77   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
POFUT2
Tbio
Family:  Enzyme
Novelty:  0.06236603
Score:  0.956
Data Source:  STRINGDB
B3GLCT
Tbio
Family:  Enzyme
Novelty:  0.02398944
Score:  0.954
Data Source:  STRINGDB
ADAMTSL2
Tbio
Novelty:  0.05511648
Score:  0.938
Data Source:  STRINGDB
ADAMTSL4
Tbio
Novelty:  0.03890484
Score:  0.932
Data Source:  STRINGDB
ADAMTS13
Tbio
Family:  Enzyme
Novelty:  0.0006095
Score:  0.928
Data Source:  STRINGDB
THSD4
Tbio
Novelty:  0.12898073
Score:  0.926
Data Source:  STRINGDB
ADAMTSL3
Tbio
Novelty:  0.07699522
Score:  0.922
Data Source:  STRINGDB
ADAMTSL1
Tbio
Novelty:  0.08853044
Score:  0.922
Data Source:  STRINGDB
THBS1
Tchem
Novelty:  0.00073905
Score:  0.92
Data Source:  STRINGDB
ADAMTS17
Tbio
Family:  Enzyme
Novelty:  0.04568792
Score:  0.919
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
7
8
16
96.8
birth weight
3
3
5
94.7
body fat distribution
3
1
5
91.3
BMI-adjusted hip circumference
2
6
8
88.3
body height
3
2
3
87.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
16
96.8
birth weight
5
94.7
body fat distribution
5
91.3
BMI-adjusted hip circumference
8
88.3
body height
3
87.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 10
VGNC:2086
107966197
Mouse
MGI:2449112
224697
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 10
VGNC:37591
611267
Horse
ADAM metallopeptidase with thrombospondin type 1 motif 10 [Source:HGNC Symbol;Acc:HGNC:13201]
Cow
ADAM metallopeptidase with thrombospondin type 1 motif 10
VGNC:25615
513140
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 10
Mouse
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 10
Horse
ADAM metallopeptidase with thrombospondin type 1 motif 10 [Source:HGNC Symbol;Acc:HGNC:13201]
Cow
ADAM metallopeptidase with thrombospondin type 1 motif 10
Publication Statistics
PubMed Score 43.77
PubMed score by year
PubTator Score 23.74
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title