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Tdark
ADAM32
Disintegrin and metalloproteinase domain-containing protein 32

Protein Summary
Description
May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein. This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. This gene is predominantly expressed in the testis. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379907
  • ENSP00000369238
  • ENSG00000197140
  • ENST00000615420
  • ENSP00000484817
  • ENSG00000275594
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
protein domain
0.97
cell type or tissue
0.74
tissue sample
0.63
cell line
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.08   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.08   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
ITGA5
Tbio
Novelty:  0.00285802
p_int:  0.999808098
p_ni:  0.000058471
p_wrong:  0.000133431
Score:  0.198
Data Source:  BioPlex,STRINGDB
STAT5B
Tchem
Family:  TF
Novelty:  0.00074178
p_int:  0.999224247
p_ni:  0.000775753
Score:  0.187
Data Source:  BioPlex,STRINGDB
ASPHD2
Tdark
Family:  Enzyme
Novelty:  1.24088719
p_int:  0.993832482
p_ni:  0.006167503
p_wrong:  1.6e-8
Data Source:  BioPlex
LCLAT1
Tbio
Family:  Enzyme
Novelty:  0.03234576
p_int:  0.983541371
p_ni:  0.016458629
Score:  0.209
Data Source:  BioPlex,STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
p_int:  0.982284194
p_ni:  0.017715798
p_wrong:  8e-9
Score:  0.174
Data Source:  BioPlex,STRINGDB
JAG2
Tbio
Novelty:  0.00176158
p_int:  0.982252907
p_ni:  0.017206138
p_wrong:  0.000540956
Score:  0.216
Data Source:  BioPlex,STRINGDB
PLXNA2
Tbio
Novelty:  0.01765957
p_int:  0.977587873
p_ni:  0.022406437
p_wrong:  0.000005691
Score:  0.158
Data Source:  BioPlex,STRINGDB
KIAA0391
Tbio
Family:  Enzyme
Novelty:  0.02276396
p_int:  0.949655815
p_ni:  0.05034409
p_wrong:  9.5e-8
Data Source:  BioPlex
ADAMTS1
Tchem
Family:  Enzyme
Novelty:  0.00483758
p_int:  0.944434909
p_ni:  0.055565091
Score:  0.217
Data Source:  BioPlex,STRINGDB
ADAM9
Tchem
Family:  Enzyme
Novelty:  0.00616626
p_int:  0.905607425
p_ni:  0.094392573
p_wrong:  1e-9
Score:  0.2
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
1
1
1
46.5
granulocyte count
1
1
1
46.5
employment status
2
1
0
1.8
22.8
employment status
2
1
0
1.8
22.8
sex hormone-binding globulin measurement
1
1
1
21.6
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
1
46.5
granulocyte count
1
46.5
employment status
0
1.8
22.8
employment status
0
1.8
22.8
sex hormone-binding globulin measurement
1
21.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase domain 32
VGNC:11932
464131
Mouse
MGI:2653822
353188
Rat
RGD:735114
361170
Dog
ADAM metallopeptidase domain 32
VGNC:37584
475578
Horse
ADAM metallopeptidase domain 32
VGNC:15056
100057132
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase domain 32
Mouse
Rat
Dog
ADAM metallopeptidase domain 32
Horse
ADAM metallopeptidase domain 32
Publication Statistics
PubMed Score 3.08
PubMed score by year
PubTator Score 1.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title