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Tdark
ADAM30
Disintegrin and metalloproteinase domain-containing protein 30

Protein Summary
Description
Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation (PubMed:27333034). This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is testis-specific and contains a polymorphic region, resulting in isoforms with varying numbers of C-terminal repeats. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369400
  • ENSP00000358407
  • ENSG00000134249

Symbol
  • svph4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
kinase perturbation
0.71
cell line
0.59
molecular function
0.49
cell type or tissue
0.45


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.17   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.17   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
MUSK
Tchem
Family:  Kinase
Novelty:  0.00151518
p_int:  0.999999779
p_ni:  2.18e-7
p_wrong:  2e-9
Score:  0.215
Data Source:  BioPlex,STRINGDB
SEC11C
Tdark
Family:  Enzyme
Novelty:  0.19577003
p_int:  0.999602788
p_ni:  0.000397194
p_wrong:  1.8e-8
Score:  0.518
Data Source:  BioPlex,STRINGDB
FOXF2
Tbio
Family:  TF
Novelty:  0.02032168
p_int:  0.96358095
p_ni:  0.008003277
p_wrong:  0.028415773
Score:  0.169
Data Source:  BioPlex,STRINGDB
SEMA6A
Tbio
Novelty:  0.00624456
p_int:  0.947289869
p_ni:  0.052542536
p_wrong:  0.000167595
Score:  0.189
Data Source:  BioPlex,STRINGDB
CANX
Tbio
Novelty:  0.00087002
p_int:  0.939635368
p_ni:  0.060364632
Score:  0.403
Data Source:  BioPlex,STRINGDB
USP30
Tchem
Family:  Enzyme
Novelty:  0.03427211
p_int:  0.920314495
p_ni:  0.079627974
p_wrong:  0.000057532
Data Source:  BioPlex
MTF2
Tbio
Family:  Epigenetic
Novelty:  0.01152147
p_int:  0.916360201
p_ni:  0.000287961
p_wrong:  0.083351838
Score:  0.228
Data Source:  BioPlex,STRINGDB
SPCS2
Tbio
Family:  Enzyme
Novelty:  0.21358992
p_int:  0.901407583
p_ni:  0.098592417
Score:  0.392
Data Source:  BioPlex,STRINGDB
ADAMTS2
Tbio
Family:  Enzyme
Novelty:  0.00852208
p_int:  0.878461828
p_ni:  0.10570461
p_wrong:  0.015833562
Score:  0.236
Data Source:  BioPlex,STRINGDB
PLXNA2
Tbio
Novelty:  0.01765957
p_int:  0.835149303
p_ni:  0.164850673
p_wrong:  2.4e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Fertilization (R-HSA-1187000)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fertilization
Reactome
Interaction With Cumulus Cells And The Zona Pellucida
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Fertilization
Interaction With Cumulus Cells And The Zona Pellucida
Reproduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
5
4
3
1.1
97.7
leukocyte count
3
3
4
94.3
neutrophil count
1
2
2
82.9
2
2
0
1.1
71.7
serum gamma-glutamyl transferase measurement
2
2
2
60.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
3
1.1
97.7
leukocyte count
4
94.3
neutrophil count
2
82.9
0
1.1
71.7
serum gamma-glutamyl transferase measurement
2
60.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1918328
71078
Rat
RGD:1594713
690547
Cow
disintegrin and metalloproteinase domain-containing protein 30
531521
Pig
ADAM metallopeptidase domain 30
100156604
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
disintegrin and metalloproteinase domain-containing protein 30
Pig
ADAM metallopeptidase domain 30
Publication Statistics
PubMed Score 4.17
PubMed score by year
PubTator Score 2.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title