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Tdark
ADAM21
Disintegrin and metalloproteinase domain-containing protein 21

Protein Summary
Description
May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene expression is testis-specific. [provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000603540
  • ENSP00000474385
  • ENSG00000139985

Symbol
  • ADAM31
  • ADAM 21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
tissue sample
0.69
cell type or tissue
0.67
cell line
0.6
molecular function
0.49


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.01   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 33   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.01   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
PCSK1N
Tbio
Novelty:  0.02656799
p_int:  0.999929937
p_ni:  0.000050964
p_wrong:  0.000019098
Score:  0.167
Data Source:  BioPlex,STRINGDB
VEGFB
Tclin
Novelty:  0.00293322
p_int:  0.999896768
p_ni:  0.000020752
p_wrong:  0.00008248
Score:  0.167
Data Source:  BioPlex,STRINGDB
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.99848557
p_ni:  0.001512793
p_wrong:  0.000001638
Data Source:  BioPlex
AMIGO1
Tbio
Novelty:  0.00864791
p_int:  0.997926733
p_ni:  0.002073249
p_wrong:  1.7e-8
Data Source:  BioPlex
P01889
Tbio
Novelty:  0.00790207
p_int:  0.992643808
p_ni:  0.007356192
Data Source:  BioPlex
EGFL7
Tbio
Novelty:  0.01148912
p_int:  0.985464699
p_ni:  0.014535169
p_wrong:  1.32e-7
Score:  0.158
Data Source:  BioPlex,STRINGDB
PATE1
Tbio
Novelty:  0.0705075
p_int:  0.977775584
p_ni:  0.003334707
p_wrong:  0.018889709
Data Source:  BioPlex
ITGB5
Tbio
Novelty:  0.01455909
p_int:  0.968887914
p_ni:  0.030766429
p_wrong:  0.000345657
Data Source:  BioPlex
GNB2
Tbio
Novelty:  0.08682553
p_int:  0.967616255
p_ni:  0.032383732
p_wrong:  1.3e-8
Data Source:  BioPlex
CANX
Tbio
Novelty:  0.00087002
p_int:  0.958777782
p_ni:  0.041222218
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Fertilization (R-HSA-1187000)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fertilization
Reactome
Interaction With Cumulus Cells And The Zona Pellucida
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Fertilization
Interaction With Cumulus Cells And The Zona Pellucida
Reproduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
2
2
84.5
low density lipoprotein cholesterol measurement
4
4
5
79.4
total cholesterol measurement
2
2
2
43.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
84.5
low density lipoprotein cholesterol measurement
5
79.4
total cholesterol measurement
2
43.9
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ADAM metallopeptidase domain 21
715640
Mouse
MGI:1861229
56622
Dog
ADAM metallopeptidase domain 21
VGNC:37579
480377
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ADAM metallopeptidase domain 21
Mouse
Dog
ADAM metallopeptidase domain 21
Publication Statistics
PubMed Score 8.01
PubMed score by year
PubTator Score 3.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title