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Tbio
ADAM2
Disintegrin and metalloproteinase domain-containing protein 2

Protein Summary
Description
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein. This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded protein is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. Alternative splicing results in multiple transcript varia ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265708
  • ENSP00000265708
  • ENSG00000104755
  • ENST00000347580
  • ENSP00000343854
  • ENST00000613160
  • ENSP00000484999
  • ENSG00000276286
  • ENST00000620181
  • ENSP00000482337

Symbol
  • FTNB
  • CT15
  • FTNB
  • PH30
  • CRYN1
  • CRYN2
  • PH-30b
  • PH30-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.73
molecular function
0.7
cell type or tissue
0.68
cell line
0.65


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.81   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.81   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
P10314
Tbio
Novelty:  0.00270731
p_int:  0.998228847
p_ni:  0.001771153
Data Source:  BioPlex
ASPHD2
Tdark
Family:  Enzyme
Novelty:  1.24088719
p_int:  0.991715374
p_ni:  0.008284615
p_wrong:  1.1e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
C6orf120
Tdark
Novelty:  0.90888293
p_int:  0.990675467
p_ni:  0.009252941
p_wrong:  0.000071592
Score:  0.239
Data Source:  BioPlex,STRINGDB
ADAMTS2
Tbio
Family:  Enzyme
Novelty:  0.00852208
p_int:  0.968215737
p_ni:  0.031784262
p_wrong:  2e-9
Score:  0.294
Data Source:  BioPlex,STRINGDB
LRRC3
Tdark
Novelty:  0.13484671
p_int:  0.929340144
p_ni:  0.00215235
p_wrong:  0.068507506
Score:  0.228
Data Source:  BioPlex,STRINGDB
TTN
Tbio
Family:  Kinase
Novelty:  0.00040356
p_int:  0.886070245
p_ni:  0.104480554
p_wrong:  0.009449201
Score:  0.426
Data Source:  BioPlex,STRINGDB
LCLAT1
Tbio
Family:  Enzyme
Novelty:  0.03234576
p_int:  0.751967728
p_ni:  0.248032264
p_wrong:  8e-9
Data Source:  BioPlex
ZP3
Tbio
Novelty:  0.00140352
Score:  0.952
Data Source:  STRINGDB
ZP2
Tbio
Novelty:  0.00310166
Score:  0.943
Data Source:  STRINGDB
CLGN
Tbio
Novelty:  0.06204915
Score:  0.939
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Fertilization (R-HSA-1187000)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fertilization
Reactome
Interaction With Cumulus Cells And The Zona Pellucida
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Fertilization
Interaction With Cumulus Cells And The Zona Pellucida
Reproduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase domain 2
VGNC:11931
464133
Macaque
ADAM metallopeptidase domain 2
707303
Mouse
MGI:1340894
11495
Rat
RGD:69299
56806
Horse
disintegrin and metalloproteinase domain-containing protein 2
100057494
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase domain 2
Macaque
ADAM metallopeptidase domain 2
Mouse
Rat
Horse
disintegrin and metalloproteinase domain-containing protein 2
Publication Statistics
PubMed Score 167.81
PubMed score by year
PubTator Score 40.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title