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Tdark
ADAM18
Disintegrin and metalloproteinase domain-containing protein 18

Protein Summary
Description
Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity). This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature sperm surface protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265707
  • ENSP00000265707
  • ENSG00000168619
  • ENST00000379866
  • ENSP00000369195
  • ENST00000520772
  • ENSP00000429908
  • ENST00000613609
  • ENSP00000482348
  • ENSG00000278548
  • ENST00000633688
  • ENSP00000488128
  • ENST00000633768
  • ENSP00000488176

Symbol
  • TMDC3
  • ADAM27
  • tMDCIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.67
cell line
0.53
molecular function
0.49
microRNA
0.45


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.99   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 35   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.99   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
HSPG2
Tbio
Family:  Enzyme
Novelty:  0.00159541
p_int:  0.999991831
p_ni:  0.000008158
p_wrong:  1e-8
Data Source:  BioPlex
LMLN
Tdark
Family:  Enzyme
Novelty:  0.00289803
p_int:  0.999172788
p_ni:  0.00050678
p_wrong:  0.000320432
Data Source:  BioPlex
CES3
Tbio
Family:  Enzyme
Novelty:  0.00938734
p_int:  0.998015755
p_ni:  0.001516036
p_wrong:  0.000468209
Data Source:  BioPlex
GALNT18
Tbio
Family:  Enzyme
Novelty:  0.15496205
p_int:  0.996847741
p_ni:  0.003149114
p_wrong:  0.000003144
Data Source:  BioPlex
SERPINF1
Tbio
Novelty:  0.00555849
p_int:  0.996841634
p_ni:  0.003156973
p_wrong:  0.000001394
Data Source:  BioPlex
SP3
Tbio
Family:  TF
Novelty:  0.00119924
p_int:  0.996562807
p_ni:  0.003317753
p_wrong:  0.000119441
Data Source:  BioPlex
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.996550075
p_ni:  0.003449491
p_wrong:  4.33e-7
Data Source:  BioPlex
NID2
Tbio
Novelty:  0.01638372
p_int:  0.996356027
p_ni:  0.003638705
p_wrong:  0.000005268
Data Source:  BioPlex
NPTX1
Tbio
Novelty:  0.02872516
p_int:  0.994908817
p_ni:  0.005091183
Data Source:  BioPlex
FKBP14
Tbio
Family:  Enzyme
Novelty:  0.02742616
p_int:  0.992469156
p_ni:  0.00751632
p_wrong:  0.000014524
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
1
1
13.5
gut microbiome measurement
1
1
1
13.5
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
13.5
gut microbiome measurement
1
13.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase domain 18
VGNC:50309
464132
Macaque
disintegrin and metalloproteinase domain-containing protein 18
701958
Mouse
MGI:105986
13524
Rat
RGD:620405
57029
Dog
ADAM metallopeptidase domain 18
VGNC:49740
607708
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase domain 18
Macaque
disintegrin and metalloproteinase domain-containing protein 18
Mouse
Rat
Dog
ADAM metallopeptidase domain 18
Publication Statistics
PubMed Score 4.99
PubMed score by year
PubTator Score 3.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title