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Tchem
ADAM17
Disintegrin and metalloproteinase domain-containing protein 17

Protein Summary
Description
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic proce ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310823
  • ENSP00000309968
  • ENSG00000151694
  • ENST00000497134
  • ENSP00000418728

Symbol
  • CSVP
  • TACE
  • CSVP
  • TACE
  • NISBD
  • ADAM18
  • CD156B
  • NISBD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase
0.95
virus perturbation
0.95
biological term
0.9
molecular function
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 878.8   (req: < 5)
Gene RIFs: 339   (req: <= 3)
Antibodies: 877   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 878.8   (req: >= 5)
Gene RIFs: 339   (req: > 3)
Antibodies: 877   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1518
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2