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Tbio
ADA2
Adenosine deaminase 2

Protein Summary
Description
Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity. This gene encodes a member of a subfamily of the adenosine deaminase protein family. The encoded protein is one of two adenosine deaminases found in humans, which regulate levels of the signaling molecule, adenosine. The encoded protein is secreted from monocytes undergoing differentiation and may regulate cell proliferation and differentiation. This gene may be responsible for some of the phenotypic features associated with cat eye syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262607
  • ENSP00000262607
  • ENSG00000093072
  • ENST00000330232
  • ENSP00000332871
  • ENST00000399837
  • ENSP00000382731
  • ENST00000399839
  • ENSP00000382733
  • ENST00000647714
  • ENSP00000497821

Symbol
  • ADGF
  • CECR1
  • IDGFL
  • PAN
  • ADGF
  • CECR1
  • IDGFL
  • SNEDS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 162   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 162   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (177)
ADK
Tchem
Family:  Kinase
Novelty:  0.00196435
Score:  0.97
Data Source:  STRINGDB
PNP
Tclin
Family:  Enzyme
Novelty:  0.0019084
Score:  0.957
Data Source:  STRINGDB
PA2G4
Tbio
Family:  Enzyme
Novelty:  0.01854234
Score:  0.948
Data Source:  STRINGDB
ADA
Tclin
Family:  Enzyme
Novelty:  0.00072339
Score:  0.945
Data Source:  STRINGDB
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
Score:  0.927
Data Source:  STRINGDB
RNASET2
Tbio
Family:  Enzyme
Novelty:  0.01939252
Score:  0.926
Data Source:  STRINGDB
RNASE2
Tchem
Family:  Enzyme
Novelty:  0.00267471
Score:  0.924
Data Source:  STRINGDB
MPO
Tchem
Family:  Enzyme
Novelty:  0.00020698
Score:  0.92
Data Source:  STRINGDB
MNDA
Tbio
Novelty:  0.01991479
Score:  0.916
Data Source:  STRINGDB
RNASE3
Tbio
Family:  Enzyme
Novelty:  0.00059878
Score:  0.912
Data Source:  STRINGDB
Nearest Tclin Targets (26)
Explore Nearest Tclin Targets
1 – 5 of 25
PDE6A
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
PNP
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
PDE1B
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
PDE7B
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
PDE6G
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
5
6
9
92.1
monocyte percentage of leukocytes
2
5
7
91.6
interleukin 17 receptor A measurement
2
6
6
91.3
leukocyte count
4
5
8
88.6
neutrophil count
2
4
6
84.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
9
92.1
monocyte percentage of leukocytes
7
91.6
interleukin 17 receptor A measurement
6
91.3
leukocyte count
8
88.6
neutrophil count
6
84.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenosine deaminase 2
VGNC:14771
458631
Macaque
adenosine deaminase 2
709295
Dog
adenosine deaminase 2
VGNC:37569
484249
Cow
adenosine deaminase 2
VGNC:54400
617805
Opossum
adenosine deaminase 2
100021637
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenosine deaminase 2
Macaque
adenosine deaminase 2
Dog
adenosine deaminase 2
Cow
adenosine deaminase 2
Opossum
adenosine deaminase 2
Publication Statistics
PubMed Score 162.00
PubMed score by year
PubTator Score 213.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title