Protein Summary
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:8452534, PubMed:16670267). Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (PubMed:20959412). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed:23193172). Stimulates plasminogen activation (PubMed:15016824). Plays a role in male fertility (PubMed:21919946, PubMed:26166670). Plays a protective role in ea ...more
- ENST00000372874
- ENSP00000361965
- ENSG00000196839
- ADA1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 0.91 | ||
gene perturbation | 0.91 | ||
disease | 0.89 | ||
disease perturbation | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1098.87 (req: < 5)
Gene RIFs: 144 (req: <= 3)
Antibodies: 460 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1098.87 (req: >= 5)
Gene RIFs: 144 (req: > 3)
Antibodies: 460 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 44
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 38
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (38)
Protein-Protein Interactions (236)
POTEF
Novelty: 0.00191599
p_int: 0.999668142
p_ni: 0.000331856
p_wrong: 2e-9
Score: 0.602
Data Source: BioPlex,STRINGDB
ACTBL2
Novelty: 0.18080702
p_int: 0.788085563
p_ni: 0.211914437
Score: 0.249
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (51)
Reactome (4)
KEGG (3)
PathwayCommons (11)
WikiPathways (33)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Reactome | Nucleotide salvage | ||||
Reactome | Purine salvage | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of nucleotides | ||||
Nucleotide salvage | ||||
Purine salvage | ||||
Viral Interactions (0)
Gene Ontology Terms (55)
Functions (3)
Components (11)
Processes (41)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
adenosine deaminase measurement | 1 | 1 | 0 | 1.1 | 80.2 | ||||
apolipoprotein A 1 measurement | 1 | 1 | 1 | 46.1 | |||||
total cholesterol measurement | 1 | 1 | 1 | 39.6 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
adenosine deaminase measurement | 0 | 1.1 | 80.2 | ||||
apolipoprotein A 1 measurement | 1 | 46.1 | |||||
total cholesterol measurement | 1 | 39.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | adenosine deaminase | VGNC:6032 | 741760 | |||||
Macaque | adenosine deaminase | 717897 | ||||||
Mouse | MGI:87916 | 11486 | ||||||
Rat | RGD:2031 | 24165 | ||||||
Dog | adenosine deaminase | VGNC:37568 | 477236 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | adenosine deaminase | |||||
Macaque | adenosine deaminase | |||||
Mouse | ||||||
Rat | ||||||
Dog | adenosine deaminase | |||||
Publication Statistics
PubMed Score 1098.87
PubMed score by year
PubTator Score 3142.13
PubTator score by year
Related Publications
Text Mined References (216)
GeneRif Annotations (144)
Items per page:
0 of 0
PMID | Year | Title |
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