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Tbio
ACY3
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)

Protein Summary
Description
Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255082
  • ENSP00000255082
  • ENSG00000132744

Symbol
  • ASPA2
  • ACY-3
  • HCBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
virus perturbation
0.68
transcription factor
0.56
tissue sample
0.52
cell line
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.78   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.78   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (10)
PMM2
Tchem
Family:  Enzyme
Novelty:  0.01177513
Score:  0.808
Data Source:  STRINGDB
ACY1
Tbio
Family:  Enzyme
Novelty:  0.00912344
Score:  0.671
Data Source:  STRINGDB
SHPK
Tbio
Family:  Kinase
Novelty:  0.16166855
Score:  0.518
Data Source:  STRINGDB
OAT
Tchem
Family:  Enzyme
Novelty:  0.00125611
Score:  0.502
Data Source:  STRINGDB
TBX10
Tbio
Family:  TF
Novelty:  0.11869902
Score:  0.49
Data Source:  STRINGDB
GORASP2
Tbio
Novelty:  0.02121907
Score:  0.48
Data Source:  STRINGDB
LACTB2
Tbio
Family:  Enzyme
Novelty:  0.1868172
Score:  0.457
Data Source:  STRINGDB
RIMKLA
Tdark
Family:  Enzyme
Novelty:  0.30213465
Score:  0.436
Data Source:  STRINGDB
ASPA
Tbio
Family:  Enzyme
Novelty:  0.02701619
Score:  0.418
Data Source:  STRINGDB
SMTNL2
Tdark
Novelty:  0.33805653
Score:  0.409
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Aflatoxin activation and detoxification (R-HSA-5423646)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aflatoxin activation and detoxification
Reactome
Biological oxidations
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Aflatoxin activation and detoxification
Biological oxidations
Metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
4
6
91.8
BMI-adjusted hip circumference
2
4
4
85.2
urinary metabolite measurement
1
1
1
51.4
BMI-adjusted waist-hip ratio
1
1
1
21.5
serum metabolite measurement
1
1
1
21.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
6
91.8
BMI-adjusted hip circumference
4
85.2
urinary metabolite measurement
1
51.4
BMI-adjusted waist-hip ratio
1
21.5
serum metabolite measurement
1
21.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aminoacylase 3
VGNC:3231
451373
Mouse
MGI:1918920
71670
Rat
RGD:1305394
293653
Anole lizard
aminoacylase 3
100558126
Xenopus
aminoacylase 3
XB-GENE-5934782
595015
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aminoacylase 3
Mouse
Rat
Anole lizard
aminoacylase 3
Xenopus
aminoacylase 3
Publication Statistics
PubMed Score 11.78
PubMed score by year
PubTator Score 10.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title