Protein Summary
Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transc ...more
- ENST00000404366
- ENSP00000384296
- ENSG00000243989
- ENST00000476351
- ENSP00000417056
- ENST00000476854
- ENSP00000419262
- ENST00000494103
- ENSP00000417618
- ENST00000636358
- ENSP00000490149
- ACY-1
- ACY1D
- HEL-S-5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.79 | ||
histone modification site profile | 0.79 | ||
transcription factor binding site profile | 0.67 | ||
disease | 0.64 | ||
PubMedID | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 114.32 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 436 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 114.32 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 436 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (55)
TRIM33
Family: Epigenetic
Novelty: 0.00415877
p_int: 0.999298204
p_ni: 0.000701796
Score: 0.206
Data Source: BioPlex,STRINGDB
PPME1
Family: Enzyme
Novelty: 0.01559862
p_int: 0.990841389
p_ni: 0.009158611
Score: 0.217
Data Source: BioPlex,STRINGDB
NUDT1
Family: Enzyme
Novelty: 0.00383386
p_int: 0.985750564
p_ni: 0.013997734
p_wrong: 0.000251703
Score: 0.799
Data Source: BioPlex,STRINGDB
SEC13
Novelty: 0.00709413
p_int: 0.958018439
p_ni: 0.041981561
Score: 0.179
Data Source: BioPlex,STRINGDB
PECR
Family: Enzyme
Novelty: 0.01550165
p_int: 0.928388137
p_ni: 0.071611863
Score: 0.313
Data Source: BioPlex,STRINGDB
PHOSPHO1
Family: Enzyme
Novelty: 0.05458897
p_int: 0.907177698
p_ni: 0.092822302
Score: 0.418
Data Source: BioPlex,STRINGDB
BOLL
Novelty: 0.02333312
p_int: 0.902165021
p_ni: 0.097834979
Score: 0.29
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (12)
Reactome (7)
KEGG (4)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Aflatoxin activation and detoxification | ||||
Reactome | Biological oxidations | ||||
Reactome | Defective ACY1 causes encephalopathy | ||||
Reactome | Disease | ||||
Reactome | Diseases of metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Aflatoxin activation and detoxification | ||||
Biological oxidations | ||||
Defective ACY1 causes encephalopathy | ||||
Disease | ||||
Diseases of metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (4)
Components (2)
Processes (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
IGF-1 measurement | 1 | 1 | 1 | 69.4 | |||||
macrophage inflammatory protein 1b measurement | 1 | 2 | 2 | 47.5 | |||||
urate measurement | 1 | 1 | 1 | 12.2 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 10.6 | |||||
apolipoprotein A 1 measurement | 1 | 1 | 1 | 8.2 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
IGF-1 measurement | 1 | 69.4 | |||||
macrophage inflammatory protein 1b measurement | 2 | 47.5 | |||||
urate measurement | 1 | 12.2 | |||||
high density lipoprotein cholesterol measurement | 1 | 10.6 | |||||
apolipoprotein A 1 measurement | 1 | 8.2 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 114.32
PubMed score by year
PubTator Score 123.81
PubTator score by year
Related Publications
Text Mined References (45)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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