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Tbio
ACY1
Aminoacylase-1

Protein Summary
Description
Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000404366
  • ENSP00000384296
  • ENSG00000243989
  • ENST00000476351
  • ENSP00000417056
  • ENST00000476854
  • ENSP00000419262
  • ENST00000494103
  • ENSP00000417618
  • ENST00000636358
  • ENSP00000490149

Symbol
  • ACY-1
  • ACY1D
  • HEL-S-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
histone modification site profile
0.79
transcription factor binding site profile
0.67
disease
0.64
PubMedID
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.32   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 436   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.32   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 436   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
TRIM33
Tchem
Family:  Epigenetic
Novelty:  0.00415877
p_int:  0.999298204
p_ni:  0.000701796
Score:  0.206
Data Source:  BioPlex,STRINGDB
PPME1
Tchem
Family:  Enzyme
Novelty:  0.01559862
p_int:  0.990841389
p_ni:  0.009158611
Score:  0.217
Data Source:  BioPlex,STRINGDB
NUDT1
Tchem
Family:  Enzyme
Novelty:  0.00383386
p_int:  0.985750564
p_ni:  0.013997734
p_wrong:  0.000251703
Score:  0.799
Data Source:  BioPlex,STRINGDB
SEC13
Tbio
Novelty:  0.00709413
p_int:  0.958018439
p_ni:  0.041981561
Score:  0.179
Data Source:  BioPlex,STRINGDB
PECR
Tbio
Family:  Enzyme
Novelty:  0.01550165
p_int:  0.928388137
p_ni:  0.071611863
Score:  0.313
Data Source:  BioPlex,STRINGDB
PHOSPHO1
Tchem
Family:  Enzyme
Novelty:  0.05458897
p_int:  0.907177698
p_ni:  0.092822302
Score:  0.418
Data Source:  BioPlex,STRINGDB
BOLL
Tbio
Novelty:  0.02333312
p_int:  0.902165021
p_ni:  0.097834979
Score:  0.29
Data Source:  BioPlex,STRINGDB
OTC
Tchem
Family:  Enzyme
Novelty:  0.00544004
Score:  0.947
Data Source:  STRINGDB
ARG2
Tchem
Family:  Enzyme
Novelty:  0.0006655
Score:  0.935
Data Source:  STRINGDB
ARG1
Tchem
Family:  Enzyme
Novelty:  0.00063728
Score:  0.933
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Aflatoxin activation and detoxification (R-HSA-5423646)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aflatoxin activation and detoxification
Reactome
Biological oxidations
Reactome
Defective ACY1 causes encephalopathy
Reactome
Disease
Reactome
Diseases of metabolism
Name
Explore in Pharos
Explore in Source
Aflatoxin activation and detoxification
Biological oxidations
Defective ACY1 causes encephalopathy
Disease
Diseases of metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
69.4
macrophage inflammatory protein 1b measurement
1
2
2
47.5
urate measurement
1
1
1
12.2
high density lipoprotein cholesterol measurement
1
1
1
10.6
apolipoprotein A 1 measurement
1
1
1
8.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
69.4
macrophage inflammatory protein 1b measurement
2
47.5
urate measurement
1
12.2
high density lipoprotein cholesterol measurement
1
10.6
apolipoprotein A 1 measurement
1
8.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 114.32
PubMed score by year
PubTator Score 123.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title