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Tchem
ACVR2A
Activin receptor type-2A

Protein Summary
Description
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity). This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This ge ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241416
  • ENSP00000241416
  • ENSG00000121989
  • ENST00000404590
  • ENSP00000384338
  • ENST00000535787
  • ENSP00000439988

Symbol
  • ACVR2
  • ACVR2
  • ACTRII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
disease perturbation
0.93
biological process
0.92
histone modification site profile
0.78
transcription factor binding site profile
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.88   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 441   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.88   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 441   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (121)
ACVR2B
Tchem
Family:  Kinase
Novelty:  0.00555742
p_int:  0.999999975
p_ni:  2e-8
p_wrong:  6e-9
Score:  0.904
Data Source:  BioPlex,Reactome,STRINGDB
LRRIQ1
Tdark
Novelty:  1.8251367
p_int:  0.998259896
p_ni:  0.001740037
p_wrong:  6.6e-8
Score:  0.208
Data Source:  BioPlex,STRINGDB
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.996202467
p_ni:  0.002660455
p_wrong:  0.001137078
Data Source:  BioPlex
MRAP2
Tbio
Novelty:  0.0420503
p_int:  0.991583972
p_ni:  0.008376435
p_wrong:  0.000039593
Data Source:  BioPlex
PCDHAC1
Tdark
Novelty:  0.3734734
p_int:  0.956033727
p_ni:  0.042932662
p_wrong:  0.001033611
Score:  0.187
Data Source:  BioPlex,STRINGDB
GINM1
Tdark
Novelty:  1.0701107
p_int:  0.948461168
p_ni:  0.05074243
p_wrong:  0.000796402
Data Source:  BioPlex
DAAM2
Tbio
Novelty:  0.07318127
p_int:  0.948074232
p_ni:  0.05154835
p_wrong:  0.000377418
Score:  0.275
Data Source:  BioPlex,STRINGDB
C16orf58
Tdark
Novelty:  0.34461652
p_int:  0.947265922
p_ni:  0.051969348
p_wrong:  0.00076473
Data Source:  BioPlex
HEPACAM2
Tbio
Novelty:  0.19192547
p_int:  0.946204062
p_ni:  0.05307707
p_wrong:  0.000718868
Data Source:  BioPlex
TLR2
Tchem
Novelty:  0.00023242
p_int:  0.944150669
p_ni:  0.055088187
p_wrong:  0.000761144
Score:  0.247
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Regulation of signaling by NODAL
Reactome
Signal Transduction
Reactome
Signaling by Activin
Reactome
Signaling by BMP
Name
Explore in Pharos
Explore in Source
Developmental Biology
Regulation of signaling by NODAL
Signal Transduction
Signaling by Activin
Signaling by BMP
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (46)
Find Similar Targets
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
3
3
3
88.8
basophil count
3
3
3
85.3
glomerular filtration rate
4
4
3
7.7
84.3
neuroticism measurement
5
8
3
6.6
81.6
eosinophil count
2
2
2
68.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
3
88.8
basophil count
3
85.3
glomerular filtration rate
3
7.7
84.3
neuroticism measurement
3
6.6
81.6
eosinophil count
2
68.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
activin A receptor type 2A
VGNC:10526
459646
Macaque
activin A receptor type 2A
707017
Mouse
MGI:102806
11480
Rat
RGD:70911
29263
Dog
activin A receptor type 2A
VGNC:37564
476140
Species
Name
OMA
EggNOG
Inparanoid
Chimp
activin A receptor type 2A
Macaque
activin A receptor type 2A
Mouse
Rat
Dog
activin A receptor type 2A
Publication Statistics
PubMed Score 145.88
PubMed score by year
PubTator Score 70.39
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title