Tbio ACVR1C Activin receptor type-1C

Protein Summary

Description

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8NER5
• Q4ZFZ8
• Q86UL1
• Q86UL2
• Q8TBG2

Gene Name

• ACVR1C

Ensembl ID

• ENST00000243349
• ENSP00000243349
• ENSG00000123612
• ENST00000335450
• ENSP00000335178
• ENST00000348328
• ENSP00000335139
• ENST00000409680
• ENSP00000387168

Symbol

• ALK7
• ALK7
• ACVRLK7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
biological process	0.92
protein domain	0.92
microRNA	0.91
gene perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Serine/threonine Protein Kinase Receptor / Activin Receptor Type-1c

Protein / Receptor / Protein Kinase Receptor / Serine/threonine Protein Kinase Receptor / Activin Receptor Type-1c

Protein / Receptor / Cytokine Receptor / Tgf-beta Receptor / Activin Receptor Type-1c

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Stkr Family / Stkr Type 1 Subfamily / Activin Receptor Type-1c

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.59   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 389   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.59   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0