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Tchem
ACVR1
Activin receptor type-1

Protein Summary
Description
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity). Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors ar ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263640
  • ENSP00000263640
  • ENSG00000115170
  • ENST00000409283
  • ENSP00000387273
  • ENST00000410057
  • ENSP00000387127
  • ENST00000434821
  • ENSP00000405004

Symbol
  • ACVRLK2
  • FOP
  • ALK2
  • SKR1
  • TSRI
  • ACTRI
  • ACVR1A
  • ACVRLK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.99
disease perturbation
0.97
protein domain
0.92
hub protein
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 522.88   (req: < 5)
Gene RIFs: 84   (req: <= 3)
Antibodies: 539   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 522.88   (req: >= 5)
Gene RIFs: 84   (req: > 3)
Antibodies: 539   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 94
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1