Protein Summary
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity). Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors ar ...more
- ENST00000263640
- ENSP00000263640
- ENSG00000115170
- ENST00000409283
- ENSP00000387273
- ENST00000410057
- ENSP00000387127
- ENST00000434821
- ENSP00000405004
- ACVRLK2
- FOP
- ALK2
- SKR1
- TSRI
- ACTRI
- ACVR1A
- ACVRLK2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 1 | ||
biological process | 0.99 | ||
disease perturbation | 0.97 | ||
protein domain | 0.92 | ||
hub protein | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 401.42 (req: < 5)
Gene RIFs: 84 (req: <= 3)
Antibodies: 539 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 401.42 (req: >= 5)
Gene RIFs: 84 (req: > 3)
Antibodies: 539 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 57
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 67
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (67)
Protein-Protein Interactions (115)
LRRIQ1
Novelty: 1.8251367
p_int: 0.999884701
p_ni: 0.000040716
p_wrong: 0.000074584
Score: 0.593
Data Source: BioPlex,STRINGDB
TNFRSF10A
Novelty: 0.0003383
p_int: 0.999864716
p_ni: 0.000077564
p_wrong: 0.00005772
Score: 0.663
Data Source: BioPlex,STRINGDB
TGFBRAP1
Novelty: 0.05996919
p_int: 0.963769973
p_ni: 0.03622065
p_wrong: 0.000009378
Score: 0.294
Data Source: BioPlex,STRINGDB
BMPR1A
Family: Kinase
Novelty: 0.00343928
p_int: 0.949442782
p_ni: 0.050554372
p_wrong: 0.000002846
Score: 0.933
Data Source: BioPlex,STRINGDB
BMPR2
Family: Kinase
Novelty: 0.00155912
p_int: 0.94729335
p_ni: 0.000047646
p_wrong: 0.052659005
Score: 0.991
Data Source: BioPlex,STRINGDB
RNF149
Family: Enzyme
Novelty: 0.64503076
p_int: 0.93758666
p_ni: 0.062223718
p_wrong: 0.000189622
Score: 0.643
Data Source: BioPlex,STRINGDB
MRAP2
Novelty: 0.0420503
p_int: 0.93482703
p_ni: 0.000051895
p_wrong: 0.065121075
Score: 0.531
Data Source: BioPlex,STRINGDB
GRAMD1A
Novelty: 0.15461113
p_int: 0.898234711
p_ni: 0.101765286
p_wrong: 2e-9
Score: 0.152
Data Source: BioPlex,STRINGDB
ACVRL1
Family: Kinase
Novelty: 0.00310167
p_int: 0.874917456
p_ni: 8e-9
p_wrong: 0.125082536
Score: 0.546
Data Source: BioPlex,STRINGDB
CD320
Novelty: 0.01978884
p_int: 0.857411228
p_ni: 0.142587369
p_wrong: 0.000001402
Score: 0.739
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (192)
KEGG (4)
PathwayCommons (13)
WikiPathways (175)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | TGF-beta signaling pathway | ||||
KEGG | Signaling pathways regulating pluripotency of stem cells | ||||
KEGG | Fluid shear stress and atherosclerosis | ||||
KEGG | Cytokine-cytokine receptor interaction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
TGF-beta signaling pathway | ||||
Signaling pathways regulating pluripotency of stem cells | ||||
Fluid shear stress and atherosclerosis | ||||
Cytokine-cytokine receptor interaction | ||||
Viral Interactions (0)
Gene Ontology Terms (61)
Functions (15)
Components (4)
Processes (42)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 2 | 4 | 5 | 82.3 | |||||
waist-hip ratio | 1 | 4 | 4 | 61.3 | |||||
waist circumference | 1 | 4 | 4 | 60.2 | |||||
reticulocyte count | 2 | 2 | 2 | 55.1 | |||||
BMI-adjusted waist circumference | 1 | 4 | 4 | 50.6 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 5 | 82.3 | |||||
waist-hip ratio | 4 | 61.3 | |||||
waist circumference | 4 | 60.2 | |||||
reticulocyte count | 2 | 55.1 | |||||
BMI-adjusted waist circumference | 4 | 50.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | activin A receptor type 1 | VGNC:56 | 470565 | |||||
Macaque | activin A receptor type 1 | 697935 | ||||||
Mouse | MGI:87911 | 11477 | ||||||
Rat | RGD:620200 | 79558 | ||||||
Dog | activin A receptor type 1 | VGNC:37561 | 478757 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | activin A receptor type 1 | |||||
Macaque | activin A receptor type 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | activin A receptor type 1 | |||||
Publication Statistics
PubMed Score 401.42
PubMed score by year
PubTator Score 213.98
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (122)
GeneRif Annotations (84)
Items per page:
0 of 0
PMID | Year | Title |
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