ACTRT2
Actin-related protein T2
Protein Summary
The protein encoded by this intronless gene belongs to the actin family. Studies have shown that this protein may be involved in cytoskeletal organization similar to other cytoplasmic actin-related protein (ARP) subfamily members. Antibody raised against the human protein has been used to detect the protein by immunoblotting and immunofluorescence microscopy, demonstrating its specific synthesis in the testis, late in spermatid differentiation, and its localization in the calyx. [provided by RefSeq, Jul 2008]
- ENST00000378404
- ENSP00000367658
- ENSG00000169717
- ARPM2
- ARPM2
- ARPT2
- Arp-T2
- HARPM2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.88 | ||
cell line | 0.5 | ||
cell type or tissue | 0.44 | ||
protein domain | 0.41 | ||
protein complex | 0.4 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.18 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 123 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.18 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 123 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 0
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (70)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (2)
Components (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet crit | 2 | 3 | 4 | 95.6 | |||||
mean platelet volume | 3 | 1 | 3 | 83.2 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 80.4 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 80.4 | |||||
mean corpuscular volume | 1 | 1 | 1 | 79.5 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet crit | 4 | 95.6 | |||||
mean platelet volume | 3 | 83.2 | |||||
mean reticulocyte volume | 1 | 80.4 | |||||
mean corpuscular hemoglobin concentration | 1 | 80.4 | |||||
mean corpuscular volume | 1 | 79.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | actin related protein T2 | VGNC:30 | 469468 | |||||
Macaque | actin related protein T2 | 711475 | ||||||
Mouse | MGI:1920603 | 73353 | ||||||
Rat | RGD:1359657 | 298671 | ||||||
Dog | actin related protein T2 | VGNC:37559 | 479581 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | actin related protein T2 | |||||
Macaque | actin related protein T2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | actin related protein T2 | |||||
Publication Statistics
PubMed Score 2.18
PubMed score by year
PubTator Score 1.67
PubTator score by year
Related Publications
Text Mined References (6)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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