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Tbio
ACTR3B
Actin-related protein 3B

Protein Summary
Description
Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors. This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256001
  • ENSP00000256001
  • ENSG00000133627
  • ENST00000377776
  • ENSP00000367007
  • ENST00000397282
  • ENSP00000380452

Symbol
  • ARP11
  • ARP4
  • ARP11
  • ARP3BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
transcription factor binding site profile
0.69
virus perturbation
0.68
tissue sample
0.67
transcription factor
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.35   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.35   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
ARPC1A
Tbio
Novelty:  0.07577807
p_int:  0.999999707
p_ni:  2.93e-7
Score:  0.981
Data Source:  BioPlex,STRINGDB
ARPC1B
Tbio
Novelty:  0.03873325
p_int:  0.9999681
p_ni:  0.0000319
Score:  0.98
Data Source:  BioPlex,STRINGDB
ARPC3
Tbio
Novelty:  0.02951522
p_int:  0.999944054
p_ni:  0.000055946
Score:  0.987
Data Source:  BioPlex,STRINGDB
ACTR2
Tchem
Novelty:  0.00731489
p_int:  0.99988571
p_ni:  0.00011429
Score:  0.984
Data Source:  BioPlex,STRINGDB
ARPC5
Tbio
Novelty:  0.03434234
p_int:  0.999885491
p_ni:  0.000114509
Score:  0.969
Data Source:  BioPlex,STRINGDB
ARPC2
Tbio
Novelty:  0.02478791
p_int:  0.999697726
p_ni:  0.000302274
Score:  0.987
Data Source:  BioPlex,STRINGDB
CHURC1
Tbio
Novelty:  0.05885372
p_int:  0.998993393
p_ni:  6.3e-8
p_wrong:  0.001006544
Score:  0.286
Data Source:  BioPlex,STRINGDB
OSBPL3
Tbio
Novelty:  0.06106368
p_int:  0.997591035
p_ni:  0.002407333
p_wrong:  0.000001632
Score:  0.223
Data Source:  BioPlex,STRINGDB
ACTR3
Tchem
Novelty:  0.02112745
p_int:  0.996287125
p_ni:  0.003712875
Score:  0.911
Data Source:  BioPlex,STRINGDB
ARPC5L
Tdark
Novelty:  0.35566409
p_int:  0.995238855
p_ni:  0.004761145
Score:  0.985
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
91.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
91.9
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ARP3 actin related protein 3 homolog B
VGNC:14002
738748
Macaque
ARP3 actin related protein 3 homolog B
715965
Mouse
MGI:2661120
242894
Cow
ARP3 actin related protein 3 homolog B
616404
Opossum
ARP3 actin related protein 3 homolog B
100019380
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ARP3 actin related protein 3 homolog B
Macaque
ARP3 actin related protein 3 homolog B
Mouse
Cow
ARP3 actin related protein 3 homolog B
Opossum
ARP3 actin related protein 3 homolog B
Publication Statistics
PubMed Score 15.35
PubMed score by year
PubTator Score 2.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title